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A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It may affect the anus, penis, scrotum, and vulva.
Features include: Neoplasm and Eczematoid dermatitis.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Neoplasm | 1 | Neoplasm |
Skin | 1 | Eczematoid dermatitis |
Biomarker and diagnostic research for extramammary Paget disease has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
11 clinical trials registered, 9 recruiting. Interventions under study include drug therapy, biologic therapy, other interventions, and procedural interventions. Pipeline includes 8 PHASE2, 1 PHASE1, 1 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06684327](https://clinicaltrials.gov/study/NCT06684327) |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 1:06 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors |
PHASE2 |
Fudan University |
RECRUITING |
[NCT06791070](https://clinicaltrials.gov/study/NCT06791070) | A Study of RC48-ADC Combined With JS001 for Advanced Extramammary Paget Disease of the Scrotum | PHASE2 | Fujian Medical University Union Hospital | RECRUITING |
[NCT03713203](https://clinicaltrials.gov/study/NCT03713203) | PAGETEX® Photodynamic Therapy Device for the Treatment of Extra Mammary Paget's Disease of the Vulva (EMPV). | NA | University Hospital, Lille | RECRUITING |
[NCT03564483](https://clinicaltrials.gov/study/NCT03564483) | Gynecologic Extramammary Paget's Disease | — | Mayo Clinic | RECRUITING |
[NCT07117851](https://clinicaltrials.gov/study/NCT07117851) | A Study of Disitamab Vedotin + Bicalutamide in HER2/AR-Positive Scrotal Paget's Disease | PHASE2 | Fudan University | RECRUITING |
245 publications have been identified in PubMed for extramammary Paget disease. Research spans Case Report / Case Series (42%), Review / Meta-Analysis (14%), and Epidemiology / Natural History (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 104 | 42% |
Research summaries | 34 | 14% |
Disease patterns and progression | 33 | 13% |
Clinical study results | 22 | 9% |
Testing and diagnosis research | 17 | 7% |
Laboratory research | 17 | 7% |
New treatment approaches | 12 | 5% |
Other research | 6 | 2% |
Villa-Gonzalez JM (2026). [PMID: 41349690](https://pubmed.ncbi.nlm.nih.gov/41349690/). *Actas Dermosifiliogr*. [Review / Meta-Analysis]
Heller A (2026). [PMID: 40960653](https://pubmed.ncbi.nlm.nih.gov/40960653/). *International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists*. [Review / Meta-Analysis]
Xiao Y (2026). [PMID: 41686451](https://pubmed.ncbi.nlm.nih.gov/41686451/). *Jpn J Clin Oncol*. [Case Report / Case Series]
Guo X (2026). [PMID: 42180745](https://pubmed.ncbi.nlm.nih.gov/42180745/). *Front Med (Lausanne)*. [Case Report / Case Series]
Lavin L (2026). [PMID: 41990219](https://pubmed.ncbi.nlm.nih.gov/41990219/). *Dermatol Surg*. [Case Report / Case Series]
Federico A (2026). [PMID: 41812374](https://pubmed.ncbi.nlm.nih.gov/41812374/). *Gynecol Oncol*. [Review / Meta-Analysis]
Jeffus SK (2026). [PMID: 41997580](https://pubmed.ncbi.nlm.nih.gov/41997580/). *Int J Gynecol Pathol*. [Diagnostic / Biomarker]
Minutilli E (2026). [PMID: 42150443](https://pubmed.ncbi.nlm.nih.gov/42150443/). *Eur J Cancer*. [Other]
Jiménez-Sánchez A MD (2026). [PMID: 41990210](https://pubmed.ncbi.nlm.nih.gov/41990210/). *Dermatol Surg*. [Clinical Trial Publication]
Zannoni GF (2026). [PMID: 41344556](https://pubmed.ncbi.nlm.nih.gov/41344556/). *Critical reviews in oncology/hematology*. [Review / Meta-Analysis]
AI-curated news mentioning extramammary Paget disease
Updated Sep 10, 2026
A new study elucidates the mechanisms underlying malignant progression in extramammary Paget's disease (EMPD), highlighting key hallmarks of the disease. This research may inform future therapeutic strategies for managing EMPD.
A recent review on extramammary Paget disease highlights the clinical features, diagnosis, and treatment options for this rare skin condition. The article consolidates current knowledge and research findings to aid in understanding this disease.
A retrospective analysis of 31 cases reveals treatment outcomes and influencing factors of photodynamic therapy in extramammary Paget's disease. This study provides insights into the efficacy of this therapy for a rare skin condition.