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A highly aggressive malignant neoplasm arising from the ovary. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.
Biomarker and diagnostic research for ovarian carcinosarcoma has been reported in the published literature.
8 clinical trials registered, 3 recruiting. Interventions under study include drug therapy, biologic therapy, procedural interventions, and other interventions. Pipeline includes 5 PHASE2, 3 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04919629](https://clinicaltrials.gov/study/NCT04919629) | APL-2 and Pembrolizumab Versus APL-2, Pembrolizumab and Bevacizumab Versus Bevacizumab Alone for the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer and Malignant Effusion | PHASE2 | Roswell Park Cancer Institute | UNKNOWN |
[NCT03449108](https://clinicaltrials.gov/study/NCT03449108) | LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas | PHASE2 | M.D. Anderson Cancer Center | UNKNOWN |
[NCT05619913](https://clinicaltrials.gov/study/NCT05619913) | EPOCH: Eribulin and Pembrolizumab in Ovarian/Uterine Carcinosarcoma | PHASE2 | Australia New Zealand Gynaecological Oncology Group | UNKNOWN |
[NCT05920798](https://clinicaltrials.gov/study/NCT05920798) | Vaccine Therapy Plus Pembrolizumab in Treating Advanced Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer | PHASE1 | Mayo Clinic | UNKNOWN |
[NCT06639074](https://clinicaltrials.gov/study/NCT06639074) | Folate Receptor Alpha Dendritic Cells (FRαDCs) or Placebo for the Treatment of Patients With Stage III or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, FAROUT Trial | PHASE2 | Mayo Clinic | RECRUITING |
55 publications have been identified in PubMed for ovarian carcinosarcoma. Research spans Case Report / Case Series (40%), Basic Science / Preclinical (16%), and Epidemiology / Natural History (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 22 | 40% |
Laboratory research | 9 | 16% |
Disease patterns and progression | 7 | 13% |
Research summaries | 6 | 11% |
Testing and diagnosis research | 5 | 9% |
Other research | 4 |
Zhao J (2026). [PMID: 41563443](https://pubmed.ncbi.nlm.nih.gov/41563443/). *Virchows Arch*. [Basic Science / Preclinical]
Abu Shamleh R (2026). [PMID: 42031396](https://pubmed.ncbi.nlm.nih.gov/42031396/). *BMJ Case Rep*. [Case Report / Case Series]
Han J (2026). [PMID: 41611572](https://pubmed.ncbi.nlm.nih.gov/41611572/). *Int J Gynecol Cancer*. [Other]
Hammer PM (2026). [PMID: 41638575](https://pubmed.ncbi.nlm.nih.gov/41638575/). *Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc*. [Epidemiology / Natural History]
Tashiro A (2026). [PMID: 41943778](https://pubmed.ncbi.nlm.nih.gov/41943778/). *Cureus*. [Basic Science / Preclinical]
Bottazzi S (2026). [PMID: 40704674](https://pubmed.ncbi.nlm.nih.gov/40704674/). *Br J Radiol*. [Review / Meta-Analysis]
Devins KM (2026). [PMID: 41801179](https://pubmed.ncbi.nlm.nih.gov/41801179/). *Am J Surg Pathol*. [Case Report / Case Series]
Abozenah Y (2026). [PMID: 41688255](https://pubmed.ncbi.nlm.nih.gov/41688255/). *Int J Gynecol Cancer*. [Other]
Farrell A (2026). [PMID: 41495830](https://pubmed.ncbi.nlm.nih.gov/41495830/). *Journal of experimental & clinical cancer research : CR*. [Gene Therapy / Novel Therapeutics]
Nakama K (2026). [PMID: 41236858](https://pubmed.ncbi.nlm.nih.gov/41236858/). *Int J Surg Pathol*. [Case Report / Case Series]
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:11 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Clinical study results | 1 | 2% |
New treatment approaches | 1 | 2% |