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Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.
Biomarker and diagnostic research for Paget disease of the nipple has been reported in the published literature.
No clinical trials have been registered for Paget disease of the nipple.
53 publications have been identified in PubMed for Paget disease of the nipple. Research spans Case Report / Case Series (58%), Review / Meta-Analysis (21%), and Diagnostic / Biomarker (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 31 | 58% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 11:26 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Paget disease of the nipple
11 |
21% |
Testing and diagnosis research | 4 | 8% |
Disease patterns and progression | 3 | 6% |
Other research | 2 | 4% |
Laboratory research | 2 | 4% |
Abdelhammed MH (2026). [PMID: 41605620](https://pubmed.ncbi.nlm.nih.gov/41605620/). *J Pathol Transl Med*. [Review / Meta-Analysis]
Volfson E (2026). [PMID: 40814164](https://pubmed.ncbi.nlm.nih.gov/40814164/). *J Cutan Med Surg*. [Review / Meta-Analysis]
Yao M (2026). [PMID: 41861228](https://pubmed.ncbi.nlm.nih.gov/41861228/). *Medicine (Baltimore)*. [Case Report / Case Series]
Sadovnikova A (2026). [PMID: 41695650](https://pubmed.ncbi.nlm.nih.gov/41695650/). *Int J Womens Dermatol*. [Epidemiology / Natural History]
Koga Y (2026). [PMID: 41982304](https://pubmed.ncbi.nlm.nih.gov/41982304/). *Surg Case Rep*. [Case Report / Case Series]
Agarwal D (2026). [PMID: 41680045](https://pubmed.ncbi.nlm.nih.gov/41680045/). *Curr Probl Diagn Radiol*. [Review / Meta-Analysis]
Yasir M (2026). [PMID: 33085375](https://pubmed.ncbi.nlm.nih.gov/33085375/). *Unknown Journal*. [Review / Meta-Analysis]
Puntos-Guizar CL (2026). [PMID: 41694995](https://pubmed.ncbi.nlm.nih.gov/41694995/). *Cureus*. [Case Report / Case Series]
Unknown (2026). [PMID: 41671500](https://pubmed.ncbi.nlm.nih.gov/41671500/). *N Engl J Med*. [Other]
Rutland CD (2026). [PMID: 41725031](https://pubmed.ncbi.nlm.nih.gov/41725031/). *Appl Immunohistochem Mol Morphol*. [Basic Science / Preclinical]
AI-curated news mentioning Paget disease of the nipple
Updated Mar 12, 2026
A retrospective case series highlights the diagnostic and therapeutic challenges faced in managing mammary and extra-mammary Paget disease. The findings underscore the need for improved strategies in diagnosis and treatment for these rare conditions.