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An adenocarcinoma arising from the pancreas. It is characterized by the presence of relatively uniform malignant cells which form acinar patterns. It usually occurs during adulthood. Signs and symptoms include abdominal pain, weight loss, nausea, and diarrhea. It may metastasize to regional lymph nodes and the liver. A minority of patients develop lipase hypersecretion syndrome. This syndrome may be seen in patients with liver metastases and it is characterized by excessive secretion of lipase in the serum, polyarthralgia, and subcutaneous fat necrosis.
Biomarker and diagnostic research for pancreatic acinar cell carcinoma has been reported in the published literature.
6 clinical trials registered, 1 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 3 PHASE2, 3 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04858334](https://clinicaltrials.gov/study/NCT04858334) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 8:41 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation |
PHASE2 |
National Cancer Institute (NCI) |
RECRUITING |
[NCT02834013](https://clinicaltrials.gov/study/NCT02834013) | Nivolumab and Ipilimumab in Treating Patients With Rare Tumors | PHASE2 | National Cancer Institute (NCI) | ACTIVE_NOT_RECRUITING |
[NCT06115499](https://clinicaltrials.gov/study/NCT06115499) | The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer | PHASE2 | Alliance for Clinical Trials in Oncology | UNKNOWN |
[NCT00669734](https://clinicaltrials.gov/study/NCT00669734) | Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery | PHASE1 | National Cancer Institute (NCI) | ACTIVE_NOT_RECRUITING |
[NCT04150042](https://clinicaltrials.gov/study/NCT04150042) | SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells | PHASE1 | General Oncology, Inc. | UNKNOWN |
145 publications have been identified in PubMed for pancreatic acinar cell carcinoma. Research spans Case Report / Case Series (39%), Basic Science / Preclinical (37%), and Review / Meta-Analysis (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 56 | 39% |
Laboratory research | 54 | 37% |
Research summaries | 12 | 8% |
Testing and diagnosis research | 10 | 7% |
Clinical study results | 6 | 4% |
Disease patterns and progression | 5 | 3% |
New treatment approaches | 2 | 1% |
Okujima Y (2026). [PMID: 41655158](https://pubmed.ncbi.nlm.nih.gov/41655158/). *Clinical journal of gastroenterology*. [Basic Science / Preclinical]
Ead AS (2026). [PMID: 41456678](https://pubmed.ncbi.nlm.nih.gov/41456678/). *J Nutr*. [Basic Science / Preclinical]
Krueger JC (2026). [PMID: 41621283](https://pubmed.ncbi.nlm.nih.gov/41621283/). *J Comp Pathol*. [Case Report / Case Series]
Miura S (2026). [PMID: 41868469](https://pubmed.ncbi.nlm.nih.gov/41868469/). *Radiol Case Rep*. [Case Report / Case Series]
Nishide S (2026). [PMID: 41484509](https://pubmed.ncbi.nlm.nih.gov/41484509/). *Clinical journal of gastroenterology*. [Case Report / Case Series]
Akiyama R (2026). [PMID: 41853419](https://pubmed.ncbi.nlm.nih.gov/41853419/). *Cureus*. [Case Report / Case Series]
Chhabra NF (2026). [PMID: 42013858](https://pubmed.ncbi.nlm.nih.gov/42013858/). *Cell Rep Methods*. [Basic Science / Preclinical]
Wei F (2026). [PMID: 41850539](https://pubmed.ncbi.nlm.nih.gov/41850539/). *Gastroenterology*. [Basic Science / Preclinical]
Keshara R (2026). [PMID: 41570824](https://pubmed.ncbi.nlm.nih.gov/41570824/). *Cell stem cell*. [Review / Meta-Analysis]
Vulovic V (2026). [PMID: 41827874](https://pubmed.ncbi.nlm.nih.gov/41827874/). *Cells*. [Review / Meta-Analysis]
AI-curated news mentioning pancreatic acinar cell carcinoma
Updated May 1, 2026
A systematic review highlights single-center experiences with pancreatic acinar cell cystadenoma, providing insights into its clinical management. This research contributes to the understanding of this rare pancreatic tumor.
A recent autopsy case study reveals multiple liver metastases originating from minute pancreatic acinar cell carcinoma, initially misdiagnosed as primary hepatic acinar cell carcinoma. This finding underscores the complexity of diagnosing pancreatic tumors and their metastatic behavior.