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parkinsonism with dementia of Guadeloupe - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

parkinsonism with dementia of Guadeloupe

MONDO:0019977

Overview

Parkinsonism with dementia of Guadeloupe is characterized by symmetrical bradykinesia, predominantly axial rigidity, postural instability with early falls and cognitive decline with prominent features of frontal lobe dysfunction.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Parkinsonism, Muscle stiffness (rigidity), and Slowness of movement (bradykinesia); and common findings: Vertical supranuclear gaze palsy, Hypometric saccades, Progressive loss of mental abilities (dementia), and Frontal lobe dementia and others.

Organ System	Phenotype Count	Example Features
Brain and nerves	15	Parkinsonism, Muscle stiffness (rigidity), Slowness of movement (bradykinesia)

Diagnosis

Biomarker and diagnostic research for parkinsonism with dementia of Guadeloupe has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 very common features, 23 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for parkinsonism with dementia of Guadeloupe.

10 publications have been identified in PubMed for parkinsonism with dementia of Guadeloupe. Research spans Epidemiology / Natural History (70%), Diagnostic / Biomarker (20%), and Clinical Trial Publication (10%).

Research Type	Count	% of Total
Disease patterns and progression	7	70%

Data assembled from 4 of 12 sources · Last updated Sep 21, 2026, 4:53 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:97355

GARD

Genetic and Rare Diseases Info Center

GARD:19372

Questions for Your Care Team

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Kisho

parkinsonism with dementia of Guadeloupe

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

parkinsonism with dementia of Guadeloupe

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications