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Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures.
Biomarker and diagnostic research for paroxysmal cold hemoglobinuria has been reported in the published literature.
Estimated prevalence: 1-9 in 1,000,000 (Rare).
No clinical trials have been registered for paroxysmal cold hemoglobinuria.
17 publications have been identified in PubMed for paroxysmal cold hemoglobinuria. Research spans Case Report / Case Series (59%), Review / Meta-Analysis (24%), and Diagnostic / Biomarker (6%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 10 | 59% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 1:14 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
4 |
24% |
Testing and diagnosis research | 1 | 6% |
Disease patterns and progression | 1 | 6% |
New treatment approaches | 1 | 6% |
Blachez M (2026). [PMID: 41118608](https://pubmed.ncbi.nlm.nih.gov/41118608/). *Blood advances*. [Case Report / Case Series]
Tripathi AK (2026). [PMID: 39163433](https://pubmed.ncbi.nlm.nih.gov/39163433/). *Unknown Journal*. [Diagnostic / Biomarker]
Fuller G (2026). [PMID: 41909291](https://pubmed.ncbi.nlm.nih.gov/41909291/). *Cureus*. [Case Report / Case Series]
Barcellini W (2025). [PMID: 41347987](https://pubmed.ncbi.nlm.nih.gov/41347987/). *Hematology. American Society of Hematology. Education Program*. [Review / Meta-Analysis]
Meloni DF (2025). [PMID: 40004813](https://pubmed.ncbi.nlm.nih.gov/40004813/). *Journal of clinical medicine*. [Review / Meta-Analysis]
Nasim S (2025). [PMID: 41473635](https://pubmed.ncbi.nlm.nih.gov/41473635/). *Cureus*. [Gene Therapy / Novel Therapeutics]
Navin N (2025). [PMID: 41244167](https://pubmed.ncbi.nlm.nih.gov/41244167/). *Asian journal of transfusion science*. [Epidemiology / Natural History]
Hiranuma N (2024). [PMID: 38072407](https://pubmed.ncbi.nlm.nih.gov/38072407/). *Internal medicine (Tokyo, Japan)*. [Case Report / Case Series]
Hirata T (2024). [PMID: 38532755](https://pubmed.ncbi.nlm.nih.gov/38532755/). *Oxford medical case reports*. [Case Report / Case Series]
Maslak İC (2024). [PMID: 39141157](https://pubmed.ncbi.nlm.nih.gov/39141157/). *Turkish archives of pediatrics*. [Case Report / Case Series]