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patent ductus venosus (PDV) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

patent ductus venosus

MONDO:0011089

Also known as:PDVPSVSportosystemic Venous shunt, congenital

Overview

Patent ductus venosus (PDV) is an extremely rare form of congenital portosystemic shunt that results in the diversion of portal blood into the systemic circulation. Failure of DV closure after birth leads to PDV. PDV results in portal venous blood bypassing the liver and directly entering the systemic circulation, decreasing hepatic blood flow and increasing blood volume and toxic substances in the systemic circulation.

GeneticsX-linked, Autosomal recessive

ResearchLimited published research (9 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Hepatic steatosis, Congenital portosystemic venous shunt, Decreased liver function, and Hypergalactosemia and 3 more.

Organ System	Phenotype Count	Example Features
Digestive system	3	Hepatic steatosis, Decreased liver function, Hepatic encephalopathy

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for patent ductus venosus.

9 publications have been identified in PubMed for patent ductus venosus. Research spans Epidemiology / Natural History (33%), Case Report / Case Series (22%), and Clinical Trial Publication (22%).

Recent Publications

Kolorz J (2026). [PMID: 41591935](https://pubmed.ncbi.nlm.nih.gov/41591935/). *J Pediatr Surg*. [Clinical Trial Publication]
Rahn A (2026). [PMID: 42209833](https://pubmed.ncbi.nlm.nih.gov/42209833/). *Eur J Pediatr*. [Epidemiology / Natural History]
Simsek AB (2025). [PMID: 41376344](https://pubmed.ncbi.nlm.nih.gov/41376344/). *Cardiol Young*. [Case Report / Case Series]
Kudo S (2025). [PMID: 40922925](https://pubmed.ncbi.nlm.nih.gov/40922925/). *Ann Gastroenterol Surg*. [Clinical Trial Publication]
Percival A (2025). [PMID: 40016160](https://pubmed.ncbi.nlm.nih.gov/40016160/). *Vet Radiol Ultrasound*. [Other]
Singh D (2025). [PMID: 39982683](https://pubmed.ncbi.nlm.nih.gov/39982683/). *Egypt Heart J*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 9:16 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:601466

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patent ductus venosus

Overview

Clinical Presentation

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

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Questions for Your Care Team

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