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pediatric acute respiratory distress syndrome (PARDS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pediatric acute respiratory distress syndrome

MONDO:0100131

Also known as:PARDS

Find Clinical TrialsTrials

Overview

Acute respiratory distress syndromet that occurs in pediatric patients and includes findings of new infiltrates (unilateral or bilateral) consistent with acute parenchymal disease, edema not fully explained by fluid overload or cardiac failure, and may present as new acute lung disease in setting of chronic lung disease and/or heart disease, and perinatal lung disease is excluded.

Clinical Trials8 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Low blood oxygen levels (hypoxemia); and common findings: Abnormal thorax morphology, Cyanosis, Premature birth, and Tachypnea and others. 16 total HPO annotations.

Organ System	Phenotype Count	Example Features
Lungs and breathing	5	Low blood oxygen levels (hypoxemia), Respiratory failure, Pulmonary edema

Diagnosis

Biomarker and diagnostic research for pediatric acute respiratory distress syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 very common feature, 8 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

8 clinical trials registered, 1 recruiting. Interventions under study include other interventions, medical devices, and procedural interventions. Pipeline includes 1 PHASE2, 5 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04068012](https://clinicaltrials.gov/study/NCT04068012)

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 10:51 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:685082

Questions for Your Care Team

→Are any of the 8 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Disease patterns and progression	28	31%
Clinical study results	18	20%
Laboratory research	13	14%
Testing and diagnosis research	12	13%
Research summaries	11	12%
Patient case studies	8	9%

Kisho

pediatric acute respiratory distress syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Analysis of the pulmonary microbiome in ARDS patients using bronchoalveolar lavage fluid metagenomic next-generation sequencing: a retrospective observational study.

ERS Congress 2025: highlights from the Paediatrics Assembly.

Veno-venous extracorporeal membrane oxygenation support for severe leptospirosis complicated by pulmonary hemorrhage and refractory acute respiratory distress syndrome: A case report and literature review.

pediatric acute respiratory distress syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Analysis of the pulmonary microbiome in ARDS patients using bronchoalveolar lavage fluid metagenomic next-generation sequencing: a retrospective observational study.

ERS Congress 2025: highlights from the Paediatrics Assembly.

Veno-venous extracorporeal membrane oxygenation support for severe leptospirosis complicated by pulmonary hemorrhage and refractory acute respiratory distress syndrome: A case report and literature review.