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adult acute respiratory distress syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

adult acute respiratory distress syndrome

MONDO:0100130

Also known as:adult ARDSadult RDSadult respiratory distress syndrome

Overview

A very severe form of acute pulmonary failure secondary to capillary permeability impairment. The symptoms include dyspnea, hypotension and multivisceral failure. The disease is characterized by bilateral pulmonary infiltrates and severe hypoxemia due to increased alveolar-capillary permeability. The severity depends on the degree of alveolar epithelial injury, with a mortality rate of 30-50%.

TreatmentsNo approved treatments · 3 in pipeline

Diagnosis

Biomarker and diagnostic research for adult acute respiratory distress syndrome has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for adult acute respiratory distress syndrome. An additional 3 compounds hold orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for adult acute respiratory distress syndrome, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for adult acute respiratory distress syndrome. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Estimated prevalence: 1-5 in 10,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for adult acute respiratory distress syndrome.

74 publications have been identified in PubMed for adult acute respiratory distress syndrome. Research spans Epidemiology / Natural History (36%), Review / Meta-Analysis (32%), and Case Report / Case Series (10%).

Research Type	Count	% of Total
Disease patterns and progression	26	36%

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 5:42 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:70578

GARD

Genetic and Rare Diseases Info Center

GARD:18902

Questions for Your Care Team

→With 3 compounds in the orphan drug pipeline, which are furthest along in development and which clinical trials should I be aware of?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

adult acute respiratory distress syndrome

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Analysis of the pulmonary microbiome in ARDS patients using bronchoalveolar lavage fluid metagenomic next-generation sequencing: a retrospective observational study.

Veno-venous extracorporeal membrane oxygenation support for severe leptospirosis complicated by pulmonary hemorrhage and refractory acute respiratory distress syndrome: A case report and literature review.

A Rare Combination of Legionella ARDS and Pulmonary Embolism: A Case Report.

adult acute respiratory distress syndrome

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Analysis of the pulmonary microbiome in ARDS patients using bronchoalveolar lavage fluid metagenomic next-generation sequencing: a retrospective observational study.

Veno-venous extracorporeal membrane oxygenation support for severe leptospirosis complicated by pulmonary hemorrhage and refractory acute respiratory distress syndrome: A case report and literature review.

A Rare Combination of Legionella ARDS and Pulmonary Embolism: A Case Report.