Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
Biomarker and diagnostic research for acute radiation syndrome has been reported in the published literature.
No approved treatments are currently available for acute radiation syndrome. An additional 19 compounds hold orphan drug designation.
While no drugs are FDA-approved specifically for acute radiation syndrome, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for acute radiation syndrome. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
Estimated prevalence: 1-9 in 1,000,000 (Rare).
No clinical trials have been registered for acute radiation syndrome.
158 publications have been identified in PubMed for acute radiation syndrome. Research spans Basic Science / Preclinical (45%), Gene Therapy / Novel Therapeutics (18%), and Review / Meta-Analysis (17%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 71 | 45% |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 1:25 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Designated
Exclusivity End |
|---|
Designation Status |
|---|
Recombinant human interleukin-7 fused to a hybrid crystallizable fragment region of a human antibody (rhIL-7-hyFc) | Recombinant human interleukin-7 fused to a hybrid crystallizable fragment region of a human antibody (rhIL-7-hyFc) | NeoImmuneTech, Inc. | 2023 | — | Designated |
3', 3, Diseleno Dipropionic Acid | 3', 3, Diseleno Dipropionic Acid | Advanced Innovative Partners, Inc. | 2021 | — | Designated |
Ulinastatin | Ulinastatin | RNR Biomedical inc | 2021 | — | Designated |
Sivelestat | Sivelestat | RNR BioMedical | 2021 | — | Designated |
geranylgeranylacetone | geranylgeranylacetone | RNR BioMedical Inc. | 2020 | — | Designated |
human platelet derived hemostatic agent | human platelet derived hemostatic agent | Cellphire, Inc. | 2020 | — | Designated |
N-(bromoacetyl)-3,3-dinitroazetidine | N-(bromoacetyl)-3,3-dinitroazetidine | EpicentRx, Inc. | 2020 | — | Designated |
a long-acting interleukin-11 analog comprised of 178 amino acids covalently modified wiht a 40-kDa branched maleimide-polyethylene glycol at the added cysteine residue following the carboxy-terminal amino acid | a long-acting interleukin-11 analog comprised of 178 amino acids covalently modified wiht a 40-kDa branched maleimide-polyethylene glycol at the added cysteine residue following the carboxy-terminal amino acid | Bolder BioTechnology, Inc. | 2019 | — | Designated |
Synthetic PreImplantation Factor | Synthetic PreImplantation Factor | BioIncept, LLC dba Prince Biotech, LLC | 2018 | — | Designated |
melatonin | melatonin | WORPHMED Srl | 2018 | — | Designated |
imidazolyl ethanamide pentandioic acid | imidazolyl ethanamide pentandioic acid | Myelo Therapeutics GmbH | 2018 | — | Designated |
indralin | indralin | Advanced Innovative Partners, Inc. | 2018 | — | Designated |
mosedipimod | mosedipimod | Enzychem Lifesciences Corporation | 2017 | — | Designated |
ex-vivo expanded placental adherent stromal cells | ex-vivo expanded placental adherent stromal cells | Pluri Biotech Ltd. | 2017 | — | Designated |
rusalatide acetate | rusalatide acetate | Chrysalis BioTherapeutics, Inc. | 2017 | — | Designated |
recombinant human interleukin-12 | recombinant human interleukin-12 | Neumedicines, Inc. | 2016 | — | Designated |
L-arginyl-L-isoleucyl-L-valyl-L-prolyl-L-alanine-amide | L-arginyl-L-isoleucyl-L-valyl-L-prolyl-L-alanine-amide | Soligenix, Inc. | 2013 | — | Designated |
recilisib sodium | recilisib sodium | Onconova Therapeutics, Inc. | 2012 | — | Withdrawn |
5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one | 5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one | Humanetics Corporation | 2007 | — | Designated |
Gene therapy approaches for acute radiation syndrome have been reported in the published literature.
View trials for acute radiation syndrome
28 |
18% |
Research summaries | 27 | 17% |
Testing and diagnosis research | 19 | 12% |
Disease patterns and progression | 7 | 4% |
Other research | 3 | 2% |
Patient case studies | 2 | 1% |
Clinical study results | 1 | 1% |
Sih BT (2026). [PMID: 41790832](https://pubmed.ncbi.nlm.nih.gov/41790832/). *PLoS One*. [Basic Science / Preclinical]
Dieffenthaller MM (2026). [PMID: 41481184](https://pubmed.ncbi.nlm.nih.gov/41481184/). *Health physics*. [Diagnostic / Biomarker]
Wang Z (2026). [PMID: 42062573](https://pubmed.ncbi.nlm.nih.gov/42062573/). *Exp Mol Med*. [Basic Science / Preclinical]
Fahl WE (2026). [PMID: 41898522](https://pubmed.ncbi.nlm.nih.gov/41898522/). *International journal of molecular sciences*. [Gene Therapy / Novel Therapeutics]
Kink JA (2026). [PMID: 41510819](https://pubmed.ncbi.nlm.nih.gov/41510819/). *Stem Cells Transl Med*. [Diagnostic / Biomarker]
Vellichirammal NN (2026). [PMID: 41125107](https://pubmed.ncbi.nlm.nih.gov/41125107/). *Radiat Res*. [Basic Science / Preclinical]
Zhang J (2026). [PMID: 41939857](https://pubmed.ncbi.nlm.nih.gov/41939857/). *Front Immunol*. [Review / Meta-Analysis]
Fazylov T (2026). [PMID: 41598251](https://pubmed.ncbi.nlm.nih.gov/41598251/). *Life (Basel)*. [Basic Science / Preclinical]
Monzen S (2026). [PMID: 42028741](https://pubmed.ncbi.nlm.nih.gov/42028741/). *Mol Med Rep*. [Diagnostic / Biomarker]
Wu T (2026). [PMID: 41161346](https://pubmed.ncbi.nlm.nih.gov/41161346/). *Radiat Res*. [Basic Science / Preclinical]