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A serious disorder characterized by massive adrenal gland hemorrhage secondary to a bacterial infection, most often Neisseria meningitidis infection. It is manifested with decreased blood pressure, shock, disseminated intravascular coagulation, and adrenocortical insufficiency.
No clinical trials have been registered for Waterhouse-Friderichsen syndrome.
8 publications have been identified in PubMed for Waterhouse-Friderichsen syndrome. Research spans Case Report / Case Series (86%) and Epidemiology / Natural History (14%).
Fort A (2026). [PMID: 41160359](https://pubmed.ncbi.nlm.nih.gov/41160359/). *Forensic Sci Med Pathol*. [Case Report / Case Series]
Liang C (2026). [PMID: 41205387](https://pubmed.ncbi.nlm.nih.gov/41205387/). *Int Immunopharmacol*. [Epidemiology / Natural History]
Ayen AA (2026). [PMID: 42254182](https://pubmed.ncbi.nlm.nih.gov/42254182/). *Ann Med Surg (Lond)*. [Case Report / Case Series]
Arvy NJ (2025). [PMID: 41555995](https://pubmed.ncbi.nlm.nih.gov/41555995/). *Cureus*. [Case Report / Case Series]
Tanaka Y (2025). [PMID: 40134911](https://pubmed.ncbi.nlm.nih.gov/40134911/). *Front Med (Lausanne)*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 6:22 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Waterhouse-Friderichsen syndrome
Santunione AL (2025). [PMID: 39787974](https://pubmed.ncbi.nlm.nih.gov/39787974/). *Leg Med (Tokyo)*. [Case Report / Case Series]