Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

Back to Pediatric High-Grade Glioma

Pediatric High-Grade Glioma — NIH Grants & Funding

Active and recent NIH-funded research on Pediatric High-Grade Glioma. Data from NIH RePORTER, last 36 months.

MONDO:1010030

NIH-funded research on Pediatric High-Grade Glioma

active grants

institutions

researchers

new in last 12 mo.

$34.3M in NIH funding over the last 36 months. Data from NIH RePORTER.

I'm looking for:

Or filter by research focus

Only show active grants

Basic Science(11)

Basic ScienceR01Active

Investigating the role of dysfunctional histone H3.3 in driving early neuronal development and pediatric high-grade gliomas

Hu, Jian·UNIVERSITY OF TX MD ANDERSON CAN CTR·HOUSTON, TX

$301,309 (FY2025)

Pediatric High-Grade Glioma — NIH Grants & Funding

Basic Science(11)

Investigating the role of dysfunctional histone H3.3 in driving early neuronal development and pediatric high-grade gliomas

Investigation of tumor stem cell maintenance and cellular hierarchy in pediatric high-grade glioma

The Role of SMARCAL1 Depletion on Increased Immunogenicity in ALT+ Gliomas

Identifying a transcriptional core regulatory circuitry and other critical transcription factor dependencies in H3.3 G34R/V high-grade glioma

Thymic PD-1 blockade mediates the anti-tumor immune response in pediatric high-grade glioma

Neurofibromin 1 as a novel regulator of lipid metabolism

Human Organoid Models for Pediatric High-Grade Gliomas

Working towards targeted therapy in H3K27M tumors: Aurora Kinase Inhibitors and the role of epigenome programming

The role of a histone point mutation in pediatric gliomagenesis

MET kinase fusions in pediatric glioblastoma

Translational(7)

Gallium maltolate for the treatment of difficult-to-treat high-grade pediatric brain tumors

Development of miRNA-based approach for pediatric high-grade gliomas

Targeting vulnerabilities of PPM1D-mutant gliomas

Targeting Transcriptional Elongation in Pediatric Glioma

Development of A High-Throughput Screen for Identification of Targeted Therapies in Brainstem Tumors with the H3K27M Mutation

SPORE: Targeted Therapies for Glioma

Development of GB13 for the Treatment of Pediatric Diffuse Intrinsic Pontine Glioma

Clinical(3)

Phase 1/2 trial of PEP-CMV + nivolumab for newly diagnosed diffuse midline glioma/high-grade glioma and recurrent diffuse midline glioma/high-grade glioma, medulloblastoma, and ependymoma (PRiME II)

Phase 2 trial of a novel peptide vaccine targeting CMV antigen for newly diagnosed pediatric high grade glioma and diffuse intrinsic pontine glioma and recurrent medulloblastoma

Phase II Clinical Trial of G207 HSV To Treat Children with High Grade Gliomas

Gene/Cell Therapy(3)

Targeting T Cells for enhancing anti-tumor immunity in pediatric brain tumors.

Addressing tumor heterogeneity in pediatric gliomas with precision adoptive T cell therapy

Defining a therapeutic platform for DIPG with mRNA CAR T cells and microglia inhibition

Biomarker / Dx(2)

Discovery of neoepitope immunotherapeutic targets in diffuse pediatric high-grade gliomas

MET kinase fusions in pediatric glioblastoma

Other(16)

Uncover the role of H3.3-G343R mutation in shaping the DNA damage response, anti-tumor immunity and mechanisms of resistance in glioma.

Epigenetic dependence of diffuse midline glioma with H3K27M mutation

The role of ATRX mutation in the epigenetic dysregulation of cell cycle in pediatric high-grade glioma

Understanding the regulation of PRC2 activity by EZHIP and the K27M oncohistone in pediatric gliomas

Enabling mRNA Therapies for Pediatric High-Grade Gliomas

Inducing H3F3A exon skipping with antisense oligonucleotides as an approach to treat diffuse intrinsic pontine glioma

Immuno-modulating Diffuse Midline Glioma by Epi-transcriptomic Reprogramming

Elucidating the interplay between H3K27M variants and DNA damage repair in diffuse midline glioma

A Phase 1b, Open-Label, Study of a Novel Targeted Radiotherapy in Children, Adolescents and Young Adults with Inoperable Relapsed or Refractory High Grade Glioma

Targeting the Mutant H3.3 Pathway in Glioma