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A rare malignant neoplasm arising from adipocytes, that occurs in children. The tumor maybe one of several histologic types including well-differentiated, dedifferentiated, myxoid/round cell, and pleomorphic liposarcoma.
Biomarker and diagnostic research for pediatric liposarcoma has been reported in the published literature.
55 clinical trials registered, 28 recruiting. Interventions under study include drug therapy, procedural interventions, biologic therapy, and other interventions. Pipeline includes 3 PHASE3, 18 PHASE2, 26 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06957431](https://clinicaltrials.gov/study/NCT06957431) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:12 PM UTC
Zanzalintinib Combined With Eribulin in Advanced Liposarcoma and Leiomyosarcoma |
PHASE1 |
Washington University School of Medicine |
RECRUITING |
[NCT06498648](https://clinicaltrials.gov/study/NCT06498648) | Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma | PHASE1 | National Cancer Institute (NCI) | RECRUITING |
[NCT06843967](https://clinicaltrials.gov/study/NCT06843967) | A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma | PHASE1 | Memorial Sloan Kettering Cancer Center | RECRUITING |
[NCT07089992](https://clinicaltrials.gov/study/NCT07089992) | A Study of Pembrolizumab in People With Ultra-Rare Sarcomas | PHASE2 | Memorial Sloan Kettering Cancer Center | RECRUITING |
[NCT07432932](https://clinicaltrials.gov/study/NCT07432932) | Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients | — | Royal Marsden NHS Foundation Trust | RECRUITING |
121 publications have been identified in PubMed for pediatric liposarcoma. Research spans Review / Meta-Analysis (25%), Basic Science / Preclinical (23%), and Case Report / Case Series (19%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 30 | 25% |
Laboratory research | 28 | 23% |
Patient case studies | 23 | 19% |
Testing and diagnosis research | 15 | 12% |
Clinical study results | 8 | 7% |
Disease patterns and progression | 7 | 6% |
New treatment approaches | 6 | 5% |
Other research | 4 | 3% |
Liu J (2026). [PMID: 42192448](https://pubmed.ncbi.nlm.nih.gov/42192448/). *J Transl Med*. [Review / Meta-Analysis]
Rubiera Valdés M (2026). [PMID: 41534314](https://pubmed.ncbi.nlm.nih.gov/41534314/). *Rev Esp Patol*. [Case Report / Case Series]
Pimenta EM (2026). [PMID: 41564157](https://pubmed.ncbi.nlm.nih.gov/41564157/). *Sci Transl Med*. [Basic Science / Preclinical]
Dupont M (2026). [PMID: 41472526](https://pubmed.ncbi.nlm.nih.gov/41472526/). *Expert Rev Anticancer Ther*. [Review / Meta-Analysis]
Hamed RR (2026). [PMID: 41782131](https://pubmed.ncbi.nlm.nih.gov/41782131/). *J Med Case Rep*. [Review / Meta-Analysis]
Omote R (2026). [PMID: 40416586](https://pubmed.ncbi.nlm.nih.gov/40416586/). *DEN Open*. [Case Report / Case Series]
Zhuang A (2026). [PMID: 42066869](https://pubmed.ncbi.nlm.nih.gov/42066869/). *Biochim Biophys Acta Rev Cancer*. [Review / Meta-Analysis]
Fan P (2026). [PMID: 42019307](https://pubmed.ncbi.nlm.nih.gov/42019307/). *Am J Surg*. [Gene Therapy / Novel Therapeutics]
Nishio J (2026). [PMID: 41482346](https://pubmed.ncbi.nlm.nih.gov/41482346/). *Cancer Genomics Proteomics*. [Review / Meta-Analysis]
Jin C (2026). [PMID: 41763312](https://pubmed.ncbi.nlm.nih.gov/41763312/). *J Biol Chem*. [Basic Science / Preclinical]
AI-curated news mentioning pediatric liposarcoma
Updated Feb 27, 2026
A recent study highlights the significant burden and unmet needs faced by liposarcoma patients in the U.S., focusing on their diagnostic journey. Insights from patient perspectives reveal critical gaps in timely diagnosis and treatment options.