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peeling skin syndrome (PSS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

peeling skin syndrome

MONDO:0019347

Also known as:PSSdeciduous skinfamilial continuous skin peeling syndrome

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Overview

Peeling skin syndrome (PSS) refers to a group of rare autosomal recessive forms of ichthyosis that is characterized clinically by superficial, asymptomatic, spontaneous peeling of the skin and histologically by a shedding of the outer layers of the epidermis. PSS presents with either an acral (acral PSS) or a generalized distribution (generalized PSS type A (non inflammatory) or B (inflammatory)). Some cases remain difficult to classify, suggesting that there could be additional subtypes of PSS.

Clinical Trials1 registered

ResearchLimited published research (8 articles)

Diagnosis

Biomarker and diagnostic research for peeling skin syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

9 publications have been identified in PubMed for peeling skin syndrome. Research spans Case Report / Case Series (50%), Diagnostic / Biomarker (13%), and Review / Meta-Analysis (13%).

Recent Publications

Szepietowska M (2026). [PMID: 41423004](https://pubmed.ncbi.nlm.nih.gov/41423004/). *J Pediatr*. [Case Report / Case Series]
Zingkou E (2025). [PMID: 40943523](https://pubmed.ncbi.nlm.nih.gov/40943523/). *Int J Mol Sci*. [Basic Science / Preclinical]
Haxho F (2025). [PMID: 40387456](https://pubmed.ncbi.nlm.nih.gov/40387456/). *Pediatr Dermatol*. [Review / Meta-Analysis]
Higashino T (2025). [PMID: 39133571](https://pubmed.ncbi.nlm.nih.gov/39133571/). *J Dermatol*. [Case Report / Case Series]
Ota VK (2025). [PMID: 40701620](https://pubmed.ncbi.nlm.nih.gov/40701620/). *Clin Exp Dermatol*. [Epidemiology / Natural History]

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 2:36 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:817

GARD

Genetic and Rare Diseases Info Center

GARD:7347

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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peeling skin syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team