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peeling skin syndrome type A - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

peeling skin syndrome type A

MONDO:0014555

Also known as:PSS type Ageneralised deciduous skin type Ageneralised peeling skin syndrome type A

Overview

Peeling skin syndrome (PSS) type A is a non inflammatory form of generalized PSS, a type of ichthyosis, characterized by generalized white scaling and superficial painless peeling of the skin.

GeneticsAutosomal recessive

ResearchLimited published research (9 articles)

Clinical Presentation

Features include always present findings: White scaling skin. 4 total HPO annotations.

Organ System	Phenotype Count	Example Features
Skin	3	Pruritus, Erythema, White scaling skin

Explore clinical features

Prognosis

Phenotype severity distribution: 1 always present feature.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for peeling skin syndrome type A.

9 publications have been identified in PubMed for peeling skin syndrome type A. Research spans Case Report / Case Series (56%), Basic Science / Preclinical (22%), and Review / Meta-Analysis (11%).

Recent Publications

Metze D (2026). [PMID: 42029647](https://pubmed.ncbi.nlm.nih.gov/42029647/). *Dermatopathology (Basel)*. [Basic Science / Preclinical]
Higashino T (2025). [PMID: 39133571](https://pubmed.ncbi.nlm.nih.gov/39133571/). *The Journal of dermatology*. [Case Report / Case Series]
Chen Y (2025). [PMID: 39377561](https://pubmed.ncbi.nlm.nih.gov/39377561/). *The Journal of dermatology*. [Case Report / Case Series]
Zingkou E (2025). [PMID: 40943523](https://pubmed.ncbi.nlm.nih.gov/40943523/). *International journal of molecular sciences*. [Basic Science / Preclinical]
Haxho F (2025). [PMID: 40387456](https://pubmed.ncbi.nlm.nih.gov/40387456/). *Pediatric dermatology*. [Review / Meta-Analysis]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 10:59 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:616265

Orphanet

European rare disease database

Orphanet:263548

GARD

Genetic and Rare Diseases Info Center

GARD:17258

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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peeling skin syndrome type A

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team