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Generalized peeling skin syndrome (PSS) is a form of PSS presenting with a generalized distribution. It comprises two sub-types: the non-inflammatory (PSS type A) and the inflammatory (PSS type B) form. PSS type A is characterized by generalized white scaling with superficial peeling of the skin, while PSS type B is characterized by superficial patchy peeling of the entire skin with underlying erythroderma, associated with pruritus, and atopy.
Biomarker and diagnostic research for generalized peeling skin syndrome has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for generalized peeling skin syndrome.
145 publications have been identified in PubMed for generalized peeling skin syndrome. Research spans Review / Meta-Analysis (28%), Basic Science / Preclinical (28%), and Epidemiology / Natural History (18%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 40 | 28% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 3:06 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research
40 |
28% |
Disease patterns and progression | 26 | 18% |
Testing and diagnosis research | 13 | 9% |
New treatment approaches | 11 | 8% |
Other research | 9 | 6% |
Clinical study results | 4 | 3% |
Patient case studies | 2 | 1% |
Olde Hartman TC (2026). [PMID: 41582038](https://pubmed.ncbi.nlm.nih.gov/41582038/). *J Psychosom Res*. [Other]
Cai X (2026). [PMID: 41646191](https://pubmed.ncbi.nlm.nih.gov/41646191/). *Front Pharmacol*. [Review / Meta-Analysis]
Hogan K (2026). [PMID: 42108468](https://pubmed.ncbi.nlm.nih.gov/42108468/). *Harm Reduct J*. [Epidemiology / Natural History]
Sahoo S (2026). [PMID: 40490070](https://pubmed.ncbi.nlm.nih.gov/40490070/). *J Shoulder Elbow Surg*. [Clinical Trial Publication]
Goyal M (2026). [PMID: 42129398](https://pubmed.ncbi.nlm.nih.gov/42129398/). *Sci Rep*. [Basic Science / Preclinical]
Li L (2026). [PMID: 41770719](https://pubmed.ncbi.nlm.nih.gov/41770719/). *Food Funct*. [Clinical Trial Publication]
Aksoy M (2026). [PMID: 41738954](https://pubmed.ncbi.nlm.nih.gov/41738954/). *Nurs Crit Care*. [Epidemiology / Natural History]
Fang L (2026). [PMID: 42142454](https://pubmed.ncbi.nlm.nih.gov/42142454/). *Eur J Med Chem*. [Basic Science / Preclinical]
Süßmuth K (2026). [PMID: 41892076](https://pubmed.ncbi.nlm.nih.gov/41892076/). *Dermatopathology (Basel)*. [Diagnostic / Biomarker]
Wang P (2026). [PMID: 41524588](https://pubmed.ncbi.nlm.nih.gov/41524588/). *Eur J Gastroenterol Hepatol*. [Diagnostic / Biomarker]