Question 1

What is acral peeling skin syndrome?

Accepted Answer

Acral peeling skin syndrome is a rare condition where the skin on the backs of the hands and feet peels off in a superficial manner. This condition is classified under peeling skin syndromes and typically affects the outermost layer of the skin on these areas.

People with this condition experience areas of peeling skin, which may be noticed without significant discomfort. The condition is known by several names, including acral PSS and peeling skin syndrome type 2, which highlights its localized nature on the extremities.

Question 2

What are the symptoms of acral peeling skin syndrome?

Accepted Answer

The main symptom of acral peeling skin syndrome is the peeling of the outer layer of the skin, most notably on the backs of the hands and feet. This peeling is usually superficial. Information about additional symptoms is currently limited for this condition.

Question 3

What causes acral peeling skin syndrome?

Accepted Answer

Acral peeling skin syndrome is associated with changes in the TGM5 gene, which plays a role in the normal function of the skin. The genetic link to TGM5 suggests that alterations in this gene may contribute to the skin peeling seen in this condition. More details about how these genetic changes lead to the symptoms are limited. Associated genes include TGM5.

Question 4

How is acral peeling skin syndrome inherited?

Accepted Answer

acral peeling skin syndrome follows an autosomal recessive inheritance pattern. This means a child must inherit a copy of the altered gene from both parents to develop the condition. Parents who each carry one copy typically do not show symptoms.

Question 5

How rare is acral peeling skin syndrome?

Accepted Answer

acral peeling skin syndrome is classified as very rare. The estimated prevalence is approximately <1 in 1,000,000. Because rare disease data can be limited, actual numbers may differ from published estimates.

Question 6

How is acral peeling skin syndrome diagnosed?

Accepted Answer

Information about diagnosis is currently limited for this condition.

Question 7

Are there treatments for acral peeling skin syndrome?

Accepted Answer

Information about treatment is currently limited for this condition.

Question 8

What complications can arise from acral peeling skin syndrome?

Accepted Answer

Currently, there is limited information about complications specifically related to acral peeling skin syndrome. Since the condition mainly causes superficial peeling of the skin on the hands and feet, most people do not experience significant discomfort. However, it is important to monitor the skin for any signs of infection or irritation, as the peeling skin may be more vulnerable.

Question 9

How does acral peeling skin syndrome affect daily life?

Accepted Answer

Acral peeling skin syndrome primarily affects the skin on the backs of the hands and feet, which can impact daily activities. People may need to be cautious with activities that involve friction or pressure on these areas. While the peeling itself may not cause significant pain, it can be a source of concern for some individuals, affecting their self-esteem and comfort.

Question 10

What is the long-term outlook for someone with acral peeling skin syndrome?

Accepted Answer

Information about the long-term outlook for individuals with acral peeling skin syndrome is currently limited. Since the condition mainly involves superficial skin peeling, many people may lead normal lives without severe complications. However, ongoing monitoring and care for the skin are important to manage symptoms effectively.

Question 11

Should families consider genetic counseling for acral peeling skin syndrome?

Accepted Answer

Since acral peeling skin syndrome is linked to changes in the TGM5 gene, families may want to consider genetic counseling. This can help them understand the inheritance patterns and the likelihood of passing the condition to future generations. A genetic counselor can provide valuable information and support for families affected by this rare condition.

Research Type	Count	% of Total
Research summaries	23	29%

Kisho

acral peeling skin syndrome

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

FAQ

Frequently Asked Questions

Recent Publications

acral peeling skin syndrome

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

FAQ

Frequently Asked Questions

What is acral peeling skin syndrome?

What are the symptoms of acral peeling skin syndrome?

What causes acral peeling skin syndrome?

How is acral peeling skin syndrome inherited?

How rare is acral peeling skin syndrome?

How is acral peeling skin syndrome diagnosed?

Are there treatments for acral peeling skin syndrome?

What complications can arise from acral peeling skin syndrome?

How does acral peeling skin syndrome affect daily life?

What is the long-term outlook for someone with acral peeling skin syndrome?

Should families consider genetic counseling for acral peeling skin syndrome?

Recent Publications