Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
Penile cancer (MONDO:0001325; Orphanet:398043) is a primary or metastatic malignant neoplasm affecting the penis. Representative histological types include penile carcinoma and penile sarcoma. Anatomically defined subtypes include glans penis cancer, penile urethral cancer, and penile sarcoma. The condition is tracked by Orphanet (Orphanet:398043) and GARD (GARD:9366) as a rare malignancy.
Certified phenotype data are not available in this packet. Penile cancer presents as a malignant neoplasm of the penis; clinical features vary by tumor subtype, anatomical site of origin, and disease stage. Further symptom detail is not certified in the available data.
Genetic basis and inheritance patterns are not specified in this packet. Penile cancer is classified as a somatic malignancy; no germline genetic basis or inheritance pattern is certified in this dataset.
Certified diagnostic methods are not specified in this packet. As a malignant neoplasm, diagnosis in clinical practice involves pathological confirmation of tumor type and staging assessment.
No treatments specifically approved for penile cancer appear in this packet. Treatment planning depends on tumor subtype, stage, anatomical location, and overall health. Management typically involves a multidisciplinary oncology team and may include surgical approaches, local therapies, systemic treatment modalities, and supportive care. Treatment goals—whether curative or focused on symptom control—are individualized based on disease characteristics.
37 trials found
Certified prognosis data are not available in this packet. Outcomes for penile cancer depend on tumor subtype, stage at diagnosis, tumor characteristics, and response to treatment.
Penile cancer is an active area of clinical investigation, with several ongoing clinical trials registered at ClinicalTrials.gov. Active and recruiting studies span drug therapy, biologic therapy, and procedural modalities across academic, government, and industry sponsors. Published literature includes 186 classified publications, predominantly review articles and meta-analyses, with ongoing research into biomarkers, HPV-associated pathways, and novel systemic treatment approaches.
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:09 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning penile cancer
Updated Sep 18, 2026
A phase II trial, MH-Penile-002, investigates a neoadjuvant treatment combining an anti-EGFR antibody-drug conjugate with a PD-1 inhibitor for penile cancer. This study focuses on patients facing challenges with penile preservation or regional lymph node metastasis.
The PERICLES trial identifies pre-existing immunity and high-risk HPV status as key factors influencing immunotherapy response in advanced penile cancer. These findings could guide future treatment strategies and patient selection.
A recent study highlights the epidemiological trends in penile cancer and discusses the evolving role of dynamic sentinel lymph node biopsy in its management. This research provides insights into the changing landscape of diagnosis and treatment for this rare disease.