Penile Cancer — Clinical Trials

MONDO:000132534 active·18 recruitingLast updated: Mar 20, 2026, 8:19 AM

Trial Landscape

Penile Cancer has an active clinical trial landscape, driven by drug treatment and procedure.

Recruiting

Active Trials

By Approach

Drug Treatment22

Procedure9

Biological Therapy8

Medical Device1

Gene Therapy1

8 additional trials involve behavioral, dietary, diagnostic, or observational approaches.

By Phase

Phase 1

Phase 2

Phase 3

9 trials are observational or have no phase designation.

Sponsor Types

Academic/Other30NIH4Industry1

Top Sponsors

Shanghai Bovax Biotechnology Co., Ltd.

Trial Locations

United States15 trials

China5 trials

Germany2 trials

Brazil2 trials

Canada2 trials

Belgium2 trials

Netherlands2 trials

Sweden1 trial

Ireland1 trial

United Kingdom1 trial

Trials often recruit across multiple countries, so totals exceed the trial count.

35 Trials

Phase 2Recruiting

NCT03866382

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Sponsor:National Cancer Institute (NCI)

United StatesStarted: May 2019Est. completion: Feb 2027Updated: Mar 2026

Phase 2Recruiting

NCT05686226

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Sponsor:Christian Hinrichs

United StatesStarted: Mar 2023Est. completion: Jan 2027Updated: Feb 2026

Phase 2Recruiting

NCT05969860

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Sponsor:Mayo Clinic

United StatesStarted: Aug 2023Est. completion: Jan 2027Updated: Feb 2026

Phase 2Recruiting

NCT06104618

Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis

Sponsor:Mayo Clinic

United StatesStarted: Dec 2023Est. completion: Nov 2026Updated: Dec 2025

Phase 2Recruiting

NCT06353906

Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer

Sponsor:The Netherlands Cancer Institute

BelgiumStarted: Aug 2024Est. completion: Jan 2028Updated: Dec 2025

Phase 2Recruiting

NCT05526989

Study of the Combination Dostarlimab With Niraparib In Patients With Penile Carcinoma

Sponsor:H. Lee Moffitt Cancer Center and Research Institute

United StatesStarted: Dec 2022Est. completion: Nov 2027Updated: Dec 2025

Phase 2Recruiting

NCT06683846

Ivonescimab in the Treatment of Multiple Advanced Tumors

Sponsor:Fudan University

ChinaStarted: Nov 2024Est. completion: Nov 2027Updated: Aug 2025

Phase 2Recruiting

NCT06415318

TIP Regimen Combined With Triplizumab Neoadjuvant Therapy for Locally Advanced Penile Cancer

Sponsor:Sun Yat-sen University

ChinaStarted: May 2024Est. completion: Dec 2027Updated: Apr 2025

Phase 2Recruiting

NCT06684327

Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors

Sponsor:Fudan University

ChinaStarted: Nov 2024Est. completion: Dec 2027Updated: Dec 2024

Phase 1Recruiting

NCT05639972

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Sponsor:Christian Hinrichs

United StatesStarted: Aug 2025Est. completion: Oct 2026Updated: Feb 2026

Phase 3Active, Not Recruiting

NCT06465914

A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males

Sponsor:Shanghai Bovax Biotechnology Co., Ltd.

ChinaStarted: Jul 2024Est. completion: Jul 2030Updated: Dec 2024

Phase 2Active, Not Recruiting

NCT03333616

Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors

Sponsor:Dana-Farber Cancer Institute

United StatesStarted: Dec 2017Est. completion: Dec 2026Updated: Jan 2026

Phase 2Active, Not Recruiting

NCT03391479

A Study of Avelumab in Penile Cancer Who Are Unfit for or Have Progressed After Platinum-Based Chemotherapy

Sponsor:University Health Network, Toronto

CanadaStarted: Aug 2018Est. completion: Dec 2026Updated: Dec 2025

Phase 2Active, Not Recruiting

NCT02817958

Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis

Sponsor:UNICANCER

FranceStarted: Oct 2016Est. completion: Sep 2028Updated: Jun 2025

Phase 2Active, Not Recruiting

NCT06638931

Agnostic Therapy in Rare Solid Tumors

Sponsor:Instituto do Cancer do Estado de São Paulo

BrazilStarted: Jul 2024Est. completion: May 2028Updated: May 2025

Phase 1Active, Not Recruiting

NCT04491942

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer

Sponsor:National Cancer Institute (NCI)

United StatesStarted: Aug 2021Est. completion: Jun 2026Updated: Mar 2026

Phase 1Active, Not Recruiting

NCT02496208

Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors

Sponsor:National Cancer Institute (NCI)

United StatesStarted: Jul 2015Est. completion: Sep 2026Updated: Mar 2026

Phase 1Active, Not Recruiting

NCT04708470

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

Sponsor:National Cancer Institute (NCI)

United StatesStarted: Oct 2021Est. completion: Nov 2026Updated: Dec 2025

Phase 1Active, Not Recruiting

NCT02379520

HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA

Sponsor:Baylor College of Medicine

United StatesStarted: Sep 2015Est. completion: Oct 2033Updated: Nov 2025

Not ApplicableActive, Not Recruiting

NCT05946993

Linking In With Advice and Supports for Men Impacted by Metastatic Cancer

Sponsor:University College Cork

IrelandStarted: May 2023Est. completion: Apr 2026Updated: Mar 2026

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Data sourced from ClinicalTrials.gov via Kisho's automated pipeline. Trials refreshed every 4 hours for monitored diseases.

Last sync: March 20, 2026 at 8:19 AM

Penile Cancer — Clinical Trials

Trial Landscape

By Approach

By Phase

Sponsor Types

Top Sponsors

Trial Locations

35 Trials

Open Trials23

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis

Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer

Study of the Combination Dostarlimab With Niraparib In Patients With Penile Carcinoma

Ivonescimab in the Treatment of Multiple Advanced Tumors

TIP Regimen Combined With Triplizumab Neoadjuvant Therapy for Locally Advanced Penile Cancer

Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Active Trials11

A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males

Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors

A Study of Avelumab in Penile Cancer Who Are Unfit for or Have Progressed After Platinum-Based Chemotherapy

Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis

Agnostic Therapy in Rare Solid Tumors

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer

Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA

Linking In With Advice and Supports for Men Impacted by Metastatic Cancer

Other1