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peripheral precocious puberty (GIPP) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

peripheral precocious puberty

MONDO:0015791

Also known as:GIPPgonadotropin independent precocious pubertyprecocious pseudopuberty

Overview

Precocious puberty caused by sex hormones.

OnsetCHILDHOOD

Newborn Screening33 states (Citrullinemia Type II)

Diagnosis

Drawn from GeneReviews diagnostic guidelines, newborn screening panel status (RUSP), and ClinGen gene-disease validity classifications. Reflects current clinical evidence and consensus where available.

Peripheral precocious puberty is included in newborn screening programs (Citrullinemia Type II) in 33 states.

Biomarker and diagnostic research for peripheral precocious puberty has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for peripheral precocious puberty.

55 publications have been identified in PubMed for peripheral precocious puberty. Research spans Case Report / Case Series (45%), Review / Meta-Analysis (18%), and Diagnostic / Biomarker (13%).

Research Type	Count	% of Total
Patient case studies	25	45%

Data assembled from 4 of 12 sources · Last updated Sep 17, 2026, 10:46 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:178040

GARD

Genetic and Rare Diseases Info Center

GARD:20141

Questions for Your Care Team

→What follow-up testing and early intervention is recommended after a positive newborn screen?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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peripheral precocious puberty

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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