Plasmodium Vivax Malaria — NIH Grants & Funding

MONDO:0005921

Funding Landscape

Plasmodium Vivax Malaria has a robust NIH research funding landscape with 29 funded grants and $47.5M in total funding over the period.

29funded grants from NIH

Portfolio: $12.8MCumulative: $47.5M21 active8 completed26 PIs17 institutions

-8% YoY(FY2024 vs FY2025)

5 new grants started in the last 12 months.

By Research Theme

Basic Science

Translational

Clinical

Epi / Nat. History

Medical Device

2 additional grants classified as “Other” (multi-disciplinary, infrastructure, etc.).

Funding by Fiscal Year

NIH fiscal year (Oct–Sep)

$10.0M

FY22

$12.5M

FY23

$11.4M

FY24

$10.5M

FY25

$3.3M

FY26

By Funding Mechanism

R01

U01

R21

ZIA

F30

F31

Basic Science(12)

Basic ScienceU44Active

Manufacture of aseptic, purified, cryopreserved Plasmodium vivax sporozoites

Chakravarty, Sumana et al.·SANARIA, INC.·ROCKVILLE, MD

$1,000,000 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Parasite and host cell factors involved in the formation and persistence of Plasmodium vivax hypnozoites

Kappe, Stefan·SEATTLE CHILDREN'S HOSPITAL·SEATTLE, WA

$836,134 (FY2026)

NIH RePORTER

Basic ScienceR01Active

Molecular basis of antimalarial drug resistance in Plasmodium vivax

Duraisingh, Manoj·HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH·BOSTON, MA

$702,840 (FY2026)

NIH RePORTER

Basic ScienceR01Active

Plasmodium vivax Erythrocyte Invasion Mechanisms and Humoral Immune Response in Duffy Negative Africans

Lo, Eugenia·DREXEL UNIVERSITY·PHILADELPHIA, PA

$644,879 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Comprehensive characterization of the genetic factors and the host immune response associated to protection from clinical Plasmodium vivax malaria

CANTAERT, TINEKE et al.·INSTITUT PASTEUR DU CAMBODGE·Phnom Penh

$579,248 (FY2026)

NIH RePORTER

Basic ScienceR61Active

Leveraging access to parasite natural diversity to identify Plasmodium vivax culture-adaptable strain.

POPOVICI, Jean·INSTITUT PASTEUR DU CAMBODGE·Phnom Penh

$265,788 (FY2026)

NIH RePORTER

Basic ScienceR21Active

Comparative transcriptomics of Plasmodium vivax strains to understand hypnozoite formation

Joyner, Chester·UNIVERSITY OF GEORGIA·ATHENS, GA

$188,750 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Host and parasite factors influencing P. vivax RBC invasion and asexual development

Serre, David·UNIVERSITY OF MARYLAND BALTIMORE·BALTIMORE, MD

$154,170 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Multi-Omics Characterization of Plasmodium Vivax Hypnozoites

Serre, David·UNIVERSITY OF MARYLAND BALTIMORE·BALTIMORE, MD

$121,824 (FY2026)

NIH RePORTER

Basic ScienceZIACompleted

Malaria Vaccines: Pvs230D1-EPA and PvCSP

Duffy, Patrick·NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

$86,556 (FY2024)

NIH RePORTER

Translational(7)

TranslationalR01Active

Lead optimization and target identification of drugs targeting hypnozoites

KYLE, DENNIS et al.·UNIVERSITY OF GEORGIA·ATHENS, GA

$649,072 (FY2024)

NIH RePORTER

TranslationalZIACompleted

Malaria Parasite Ligands And Host Cell Receptors

Miller, Louis·NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

$451,731 (FY2025)

NIH RePORTER

TranslationalZIACompleted

Identification of Novel antimalarial drugs targeting asexual blood stage of P. Vivax

Rai Bantukallu, Ganesha·NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

$425,400 (FY2022)

NIH RePORTER

TranslationalU01Active

Optimizing the dose of tafenoquine for the radical cure of Plasmodium vivax malaria in Southeast Asia

Chu, Cindy·UNIVERSITY OF OXFORD·OXFORD

$117,395 (FY2025)

NIH RePORTER

TranslationalR01Active

Extent, dynamics and mechanisms of Plasmodium vivax immune evasion caused by PvDBP gene amplification

Lo, Eugenia et al.·INSTITUT PASTEUR DU CAMBODGE·Phnom Penh

$63,525 (FY2025)

NIH RePORTER

TranslationalR01Completed

Development of a pre-erythrocytic P. vivax vaccine to prevent clinical relapse

Sather, D.·SEATTLE CHILDREN'S HOSPITAL·SEATTLE, WA

$822,542 (FY2023)

NIH RePORTER

TranslationalU01Completed

DISCOVERY AND PRECLINICAL DEVELOPMENT OF EFFICACIOUS P. vivax PRE-ERYTHROCYTIC STAGE MALARIA VACCINES

Herrera Valencia, Socrates·CAUCASECO SCIENTIFIC RESEARCH CENTER·CALI

$582,163 (FY2023)

NIH RePORTER

Clinical(5)

ClinicalU01Active

Accelerating discovery of an efficacious Plasmodium vivax multivalent multi-stage vaccine

Adams, John·UNIVERSITY OF SOUTH FLORIDA·TAMPA, FL

$882,985 (FY2025)

NIH RePORTER

ClinicalU01Active

Focal mass drug administration (fMDA) to reduce Plasmodium vivax transmission, a pragmatic cluster randomized controlled trial in Peru

Hsiang, Michelle·UNIVERSITY OF CALIFORNIA, SAN FRANCISCO·SAN FRANCISCO, CA

$668,530 (FY2025)

NIH RePORTER

ClinicalR01Active

Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure

Serre, David·UNIVERSITY OF MARYLAND BALTIMORE·BALTIMORE, MD

$503,963 (FY2024)

NIH RePORTER

ClinicalR21Active

Applying novel tools to parse Plasmodium vivax relapses in clinical trials

Lin, Jessica·UNIV OF NORTH CAROLINA CHAPEL HILL·CHAPEL HILL, NC

$190,825 (FY2026)

NIH RePORTER

ClinicalR01Completed

Primaquine metabolism and treatment of P. vivax in Madagascar

Williams, Scott et al.·CASE WESTERN RESERVE UNIVERSITY·CLEVELAND, OH

$227,028 (FY2023)

NIH RePORTER

Epi / Nat. History(2)

Epi / Nat. HistoryR21Active

A longitudinal cohort study of Plasmodium vivax relapses in Central Africa

Lo, Eugenia·DREXEL UNIVERSITY·PHILADELPHIA, PA

$140,257 (FY2025)

NIH RePORTER

Epi / Nat. HistoryF31Completed

Epidemiology of Plasmodium vivax in Ethiopia in varying Duffy Phenotypes

Bradley, Lauren·UNIVERSITY OF CALIFORNIA-IRVINE·IRVINE, CA

$43,782 (FY2023)

NIH RePORTER

Medical Device(1)

Medical DeviceR44Completed

Manufacture of aseptic, purified, cryopreserved Plasmodium vivax sporozoites

Chakravarty, Sumana et al.·SANARIA, INC.·ROCKVILLE, MD

$961,340 (FY2022)

NIH RePORTER

Other(2)

OtherR01Active

Immunological characterization of the P. vivax DBP

Adams, John·UNIVERSITY OF SOUTH FLORIDA·TAMPA, FL

$577,726 (FY2023)

NIH RePORTER

OtherF30Completed

Identifying the Distribution, Origin, and Threat of Plasmodium vivax in the DRC

Brazeau, Nicholas·UNIV OF NORTH CAROLINA CHAPEL HILL·CHAPEL HILL, NC

$41,508 (FY2022)

NIH RePORTER

Adjacent Research(3 grants)

These grants mention Plasmodium Vivax Malaria as part of broader research but are not primarily focused on this disease. They are not included in the funding totals above.

Other(3)

OtherU19Active

Understanding and Targeting the Barriers to Effective Malaria Control and Elimination in the Asia-Pacific Region

Mueller, Ivo et al.·WALTER AND ELIZA HALL INST MEDICAL RES·Parkville

$191,687 (FY2025)

NIH RePORTER

OtherU19Completed

Environmental Modifications in sub-Saharan Africa: Changing Epidemiology, Transmission and Pathogenesis of Plasmodium falciparum and P. vivax Malaria

Yan, Guiyun·UNIVERSITY OF CALIFORNIA-IRVINE·IRVINE, CA

$3,097,164 (FY2023)

NIH RePORTER

OtherR01Completed

Discovery and preclinical evaluation of Plasmodium falciparum and P. vivax coiled coil antigens for malaria vaccine development

Herrera Valencia, Socrates·CAUCASECO SCIENTIFIC RESEARCH CENTER·CALI

$319,458 (FY2022)

NIH RePORTER

Top Funded Institutions

SANARIA, INC.$2.0M

MD2 grantsChakravarty, Sumana, HOFFMAN, STEPHEN

SEATTLE CHILDREN'S HOSPITAL$1.7M

WA2 grantsKappe, Stefan, Sather, D.

UNIVERSITY OF SOUTH FLORIDA$1.5M

FL2 grantsAdams, John

CASE WESTERN RESERVE UNIVERSITY$924K

OH2 grantsKing, Christopher, Williams, Scott +1

INSTITUT PASTEUR DU CAMBODGE$909K

3 grantsLo, Eugenia, POPOVICI, Jean +1

UNIVERSITY OF GEORGIA$838K

GA2 grantsJoyner, Chester, KYLE, DENNIS +1

DREXEL UNIVERSITY$785K

PA2 grantsLo, Eugenia

UNIVERSITY OF MARYLAND BALTIMORE$780K

MD3 grantsSerre, David

HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH$703K

MA1 grantDuraisingh, Manoj

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO$669K

CA1 grantHsiang, Michelle

Top Principal Investigators

Chakravarty, Sumana$2.0M

SANARIA, INC.·2 grants

Basic ScienceMedical Device

HOFFMAN, STEPHEN$2.0M

SANARIA, INC.·2 grants

Basic ScienceMedical Device

Adams, John$1.5M

UNIVERSITY OF SOUTH FLORIDA·2 grants

OtherClinical

POPOVICI, Jean$909K

INSTITUT PASTEUR DU CAMBODGE·3 grants

TranslationalBasic Science

Lo, Eugenia$849K

DREXEL UNIVERSITY·3 grants

Basic ScienceTranslationalEpi / Nat. History

Kappe, Stefan$836K

SEATTLE CHILDREN'S HOSPITAL·1 grant

Basic Science

Sather, D.$823K

SEATTLE CHILDREN'S HOSPITAL·1 grant

Translational

Serre, David$780K

UNIVERSITY OF MARYLAND BALTIMORE·3 grants

Basic ScienceClinical

Duraisingh, Manoj$703K

HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH·1 grant

Basic Science

King, Christopher$697K

CASE WESTERN RESERVE UNIVERSITY·1 grant

Basic Science

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