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Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney.
Biomarker and diagnostic research for polyarteritis nodosa has been reported in the published literature.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
6 clinical trials registered, 6 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 1 PHASE2. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT02257866](https://clinicaltrials.gov/study/NCT02257866) |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 8:12 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
— |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
RECRUITING |
[NCT02593565](https://clinicaltrials.gov/study/NCT02593565) | Vasculitis Pregnancy Registry | — | University of Pennsylvania | RECRUITING |
[NCT02939573](https://clinicaltrials.gov/study/NCT02939573) | A Randomized Multicenter Study for Isolated Skin Vasculitis | PHASE2 | University of Pennsylvania | RECRUITING |
[NCT01241305](https://clinicaltrials.gov/study/NCT01241305) | One-Time DNA Study for Vasculitis | — | University of Pennsylvania | RECRUITING |
[NCT02967068](https://clinicaltrials.gov/study/NCT02967068) | VCRC Tissue Repository | — | University of Pennsylvania | RECRUITING |
190 publications have been identified in PubMed for polyarteritis nodosa. Kisho has analyzed 129 by research type. Research spans Case Report / Case Series (44%), Review / Meta-Analysis (22%), and Epidemiology / Natural History (12%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 57 | 44% |
Research summaries | 29 | 22% |
Disease patterns and progression | 15 | 12% |
Testing and diagnosis research | 12 | 9% |
Other research | 9 | 7% |
Clinical study results | 4 | 3% |
Laboratory research | 2 | 2% |
New treatment approaches | 1 | 1% |
Torun ES (2026). [PMID: 41066191](https://pubmed.ncbi.nlm.nih.gov/41066191/). *Clin Exp Rheumatol*. [Review / Meta-Analysis]
Yue J (2026). [PMID: 41147740](https://pubmed.ncbi.nlm.nih.gov/41147740/). *Arthritis Rheumatol*. [Diagnostic / Biomarker]
Yaprak Bayrak B (2026). [PMID: 41576836](https://pubmed.ncbi.nlm.nih.gov/41576836/). *Ann Diagn Pathol*. [Case Report / Case Series]
Martinage N (2026). [PMID: 42014235](https://pubmed.ncbi.nlm.nih.gov/42014235/). *Semin Nucl Med*. [Review / Meta-Analysis]
Nimbvikar A (2026). [PMID: 41615024](https://pubmed.ncbi.nlm.nih.gov/41615024/). *Mod Rheumatol Case Rep*. [Review / Meta-Analysis]
Taprantzis N (2026). [PMID: 41711936](https://pubmed.ncbi.nlm.nih.gov/41711936/). *Rheumatol Int*. [Review / Meta-Analysis]
Amikam U (2026). [PMID: 42223974](https://pubmed.ncbi.nlm.nih.gov/42223974/). *Int J Gynaecol Obstet*. [Epidemiology / Natural History]
Cioni P (2026). [PMID: 41437650](https://pubmed.ncbi.nlm.nih.gov/41437650/). *Rheumatology (Oxford)*. [Epidemiology / Natural History]
Cottu A (2026). [PMID: 41369608](https://pubmed.ncbi.nlm.nih.gov/41369608/). *J Am Acad Dermatol*. [Clinical Trial Publication]
Fujikake T (2026). [PMID: 42207464](https://pubmed.ncbi.nlm.nih.gov/42207464/). *Clin Rheumatol*. [Review / Meta-Analysis]