Polymicrogyria — Clinical Trials

MONDO:00000872 active·2 recruitingLast updated: Mar 18, 2026, 6:46 PM

Trial Landscape

Polymicrogyria has an emerging clinical trial program, driven by drug treatment and procedure.

Recruiting

Active Trials

By Approach

Drug Treatment2

Procedure1

By Phase

Phase 2

Sponsor Types

Academic/Other1Industry1

Top Sponsors

Relay Therapeutics, Inc.

Trial Locations

France1 trial

United States1 trial

Australia1 trial

Belgium1 trial

Italy1 trial

Spain1 trial

United Kingdom1 trial

Trials often recruit across multiple countries, so totals exceed the trial count.

2 Trials

Phase 2Recruiting

NCT05577754

Assessment of the Efficacy and Safety of Alpelisib (BYL719) in Pediatric and Adult Patients With Megalencephaly-CApillary Malformation Polymicrogyria Syndrome (MCAP)

Sponsor:Centre Hospitalier Universitaire Dijon

FranceStarted: Nov 2022Est. completion: Mar 2027Updated: Feb 2026

Phase 2Recruiting

NCT06789913

A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation

Sponsor:Relay Therapeutics, Inc.

United StatesStarted: Jun 2025Est. completion: Oct 2031Updated: Jan 2026

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Data sourced from ClinicalTrials.gov via Kisho's automated pipeline. Trials refreshed every 4 hours for monitored diseases.

Last sync: March 18, 2026 at 6:46 PM