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prelingual non-syndromic genetic hearing loss - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

prelingual non-syndromic genetic hearing loss

MONDO:0016297

Also known as:isolated prelingual genetic deafnessprelingual non-syndromic genetic deafness

Overview

A rare, genetically highly heterogeneous otorhinolaryngologic disease, resulting from inner and/or middle ear or hearing nerve anomalies, typically characterized by bilateral, severe to profound hearing loss (mean sensorineural hearing impairment of 60 dB or more for 500-, 1,000-, and 2,000-Hz frequency tones in the better ear) which occurs before the onset of speech development and is not associated with visible external ear abnormalities or any other medical problems. It is usually nonprogressive and impedes oral language acquisition.

Patient Orgs1 organizations · NET (Neuroendocrine Tumor) Research Foundation

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for prelingual non-syndromic genetic hearing loss.

21 publications have been identified in PubMed for prelingual non-syndromic genetic hearing loss. Research spans Basic Science / Preclinical (33%), Case Report / Case Series (24%), and Epidemiology / Natural History (24%).

Research Type	Count	% of Total
Laboratory research	7	33%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 12:33 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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NET (Neuroendocrine Tumor) Research FoundationPrimary Focus

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Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:216445

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with NET (Neuroendocrine Tumor) Research Foundation and other patient organizations for support?

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prelingual non-syndromic genetic hearing loss

Overview

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications