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Primary lymphoma of the conjunctiva is an extremely rare clonal lymphoid proliferation of the ocular surface, with an indolent course. Clinically it presents with treatment-resistant conjunctivitis, ptosis, excessive tear production or as a painless, salmon-pink, ''fleshy'' patch, with a smooth or multinodular surface, on the bulbar conjunctiva. Histologically it is usually B-cell Non-Hodgkin lymphoma (most often extranodal marginal zone B-cell lymphoma, followed by follicular and diffuse large B-cell lymphoma), with conjunctival T-cell Non-Hodgkin lymphoma being very rare.
Biomarker and diagnostic research for primary lymphoma of the conjunctiva has been reported in the published literature.
No clinical trials have been registered for primary lymphoma of the conjunctiva.
46 publications have been identified in PubMed for primary lymphoma of the conjunctiva. Research spans Case Report / Case Series (61%), Epidemiology / Natural History (13%), and Review / Meta-Analysis (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 28 | 61% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:33 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Disease patterns and progression
6 |
13% |
Research summaries | 5 | 11% |
Testing and diagnosis research | 3 | 7% |
Clinical study results | 3 | 7% |
Laboratory research | 1 | 2% |
Ortiz A (2026). [PMID: 42090215](https://pubmed.ncbi.nlm.nih.gov/42090215/). *J Craniofac Surg*. [Case Report / Case Series]
Geiger F (2026). [PMID: 41638221](https://pubmed.ncbi.nlm.nih.gov/41638221/). *Klinische Monatsblatter fur Augenheilkunde*. [Case Report / Case Series]
Flaifel A (2026). [PMID: 41225296](https://pubmed.ncbi.nlm.nih.gov/41225296/). *The American journal of surgical pathology*. [Basic Science / Preclinical]
Li Y (2026). [PMID: 40607701](https://pubmed.ncbi.nlm.nih.gov/40607701/). *Cornea*. [Case Report / Case Series]
Panda BB (2026). [PMID: 41986061](https://pubmed.ncbi.nlm.nih.gov/41986061/). *BMJ Case Rep*. [Case Report / Case Series]
Reddy M (2026). [PMID: 40247460](https://pubmed.ncbi.nlm.nih.gov/40247460/). *Clinical nuclear medicine*. [Diagnostic / Biomarker]
Loap P (2026). [PMID: 41654479](https://pubmed.ncbi.nlm.nih.gov/41654479/). *Clinical lymphoma, myeloma & leukemia*. [Case Report / Case Series]
Nuessle S (2026). [PMID: 41545984](https://pubmed.ncbi.nlm.nih.gov/41545984/). *BMC Ophthalmol*. [Review / Meta-Analysis]
Callet M (2026). [PMID: 41505142](https://pubmed.ncbi.nlm.nih.gov/41505142/). *JAMA ophthalmology*. [Case Report / Case Series]
Mehal S (2026). [PMID: 41443004](https://pubmed.ncbi.nlm.nih.gov/41443004/). *Journal francais d'ophtalmologie*. [Case Report / Case Series]
AI-curated news mentioning primary lymphoma of the conjunctiva
Updated May 4, 2026
A case study highlights primary lymphoma of the acromion as a rare cause of isolated shoulder pain. This discovery emphasizes the need for awareness of atypical presentations in lymphoma diagnosis.