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progressive bulbar palsy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

progressive bulbar palsy

MONDO:0008890

Also known as:Fazio-Londe diseasebulbar palsy, progressive, of childhoodprogressive bulbar atrophy

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Overview

Progressive bulbar palsy involves the brain stem. The brain stem is the part of the brain needed for swallowing, speaking, chewing, and other functions. Signs and symptoms of progressive bulbar palsy include difficulty swallowing, weak jaw and facial muscles, progressive loss of speech, and weakening of the tongue. Additional symptoms include less prominent weakness in the arms and legs, and outbursts of laughing or crying (called emotional lability). Progressive bulbar palsy is considered a variant form of amyotrophic lateral sclerosis (ALS). Many people with progressive bulbar palsy later develop ALS. While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms.

Clinical Trials3 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for progressive bulbar palsy has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 1 recruiting. Interventions under study include other interventions. Pipeline includes 2 NA. Research is primarily sponsored by academic and government institutions.

142 publications have been identified in PubMed for progressive bulbar palsy. Research spans Case Report / Case Series (37%), Review / Meta-Analysis (18%), and Epidemiology / Natural History (16%).

Research Type	Count	% of Total
Patient case studies	53

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 9:18 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

GARD

Genetic and Rare Diseases Info Center

GARD:10928

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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progressive bulbar palsy

Overview

Diagnosis

Research Landscape

Medical References

External Resources

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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