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Progressive cavitating leukoencephalopathy is characterized by acute episodes of neurological deficit (ataxia, dysarthria, seizures) with irritability and opisthotonus followed by either steady deterioration or alternating periods of rapid progression and prolonged periods of stability.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for progressive cavitating leukoencephalopathy.
4 publications have been identified in PubMed for progressive cavitating leukoencephalopathy. Research spans Case Report / Case Series (75%) and Other (25%).
Xiaowei L (2026). [PMID: 41952138](https://pubmed.ncbi.nlm.nih.gov/41952138/). *BMC pediatrics*. [Case Report / Case Series]
Ferreira EO (2025). [PMID: 40415601](https://pubmed.ncbi.nlm.nih.gov/40415601/). *Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society*. [Case Report / Case Series]
Caliskan E (2024). [PMID: 39634239](https://pubmed.ncbi.nlm.nih.gov/39634239/). *Molecular syndromology*. [Case Report / Case Series]
Ghiglieri V (2024). [PMID: 38784711](https://pubmed.ncbi.nlm.nih.gov/38784711/). *Front Cell Neurosci*. [Other]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 10:41 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center