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progressive familial heart block (PFHB) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

progressive familial heart block

MONDO:0019490

Also known as:PFHBfamilial Lenegre diseasefamilial Lenègre disease

Overview

A hereditary cardiac conduction disorder that may progress to complete atrioventricular (AV) block. The disease is either asymptomatic or manifests as dyspnea, dizziness, syncope, abdominal pain, heart failure or sudden death.

Diagnosis

Biomarker and diagnostic research for progressive familial heart block has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for progressive familial heart block.

23 publications have been identified in PubMed for progressive familial heart block. Research spans Epidemiology / Natural History (22%), Review / Meta-Analysis (17%), and Case Report / Case Series (17%).

Research Type	Count	% of Total
Disease patterns and progression	5	22%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:45 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:871

GARD

Genetic and Rare Diseases Info Center

GARD:10005

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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progressive familial heart block

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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