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Progressive non-infectious anterior vertebral fusion (PAVF) is an early childhood spinal disorder characterized by the gradual onset of thoracic and/or lumbar spine ankylosis often in conjunction with kyphosis with distinctive radiological features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for progressive non-infectious anterior vertebral fusion.
5 publications have been identified in PubMed for progressive non-infectious anterior vertebral fusion. Research spans Case Report / Case Series (60%), Other (20%), and Epidemiology / Natural History (20%).
Liu Z (2026). [PMID: 41391843](https://pubmed.ncbi.nlm.nih.gov/41391843/). *Orthop Surg*. [Case Report / Case Series]
Woods E (2025). [PMID: 40256810](https://pubmed.ncbi.nlm.nih.gov/40256810/). *Am J Med Genet A*. [Case Report / Case Series]
Asunis E (2025). [PMID: 39860381](https://pubmed.ncbi.nlm.nih.gov/39860381/). *J Clin Med*. [Case Report / Case Series]
Kramer A (2025). [PMID: 40007800](https://pubmed.ncbi.nlm.nih.gov/40007800/). *Brain Spine*. [Epidemiology / Natural History]
Stip E (2024). [PMID: 39656569](https://pubmed.ncbi.nlm.nih.gov/39656569/). *Sante Ment Que*. [Other]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 12:33 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center