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A respiratory disease due to repeated episodes of diffuse alveolar hemorrhage without any underlying apparent cause, most often in children. Anemia, cough, and pulmonary infiltrates on chest radiographs are found in majority of the patients.
Features include very common findings: Low iron red blood cell count (iron deficiency anemia); and common findings: Hemoptysis, Pallor, Hepatosplenomegaly, and Pulmonary infiltrates and others. 32 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Lungs and breathing | 9 | Transient pulmonary infiltrates, Difficulty breathing (respiratory insufficiency), Lung scarring (pulmonary fibrosis) |
Biomarker and diagnostic research for pulmonary hemosiderosis has been reported in the published literature.
Phenotype severity distribution: 1 very common feature, 7 common features.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE1. Research is primarily sponsored by academic and government institutions.
29 publications have been identified in PubMed for pulmonary hemosiderosis. Research spans Case Report / Case Series (59%), Review / Meta-Analysis (21%), and Epidemiology / Natural History (10%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 17 |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 7:49 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Lab test results |
4 |
Anti-smooth muscle antibody positivity, Antineutrophil antibody positivity, Antinuclear antibody positivity |
Blood and immune system | 2 | Low iron red blood cell count (iron deficiency anemia), Autoimmune antibody positivity |
Digestive system | 2 | Hepatosplenomegaly, Enlarged liver (hepatomegaly) |
Heart and blood vessels | 2 | Enlarged heart (cardiomegaly), Heart murmur |
Brain and nerves | 1 | Fatigue |
Growth and development | 1 | Failure to thrive |
Metabolism | 1 | Fever |
Muscles | 1 | Anti-smooth muscle antibody positivity |
Kidneys and urinary system | 1 | Glomerulonephritis |
Research summaries | 6 | 21% |
Disease patterns and progression | 3 | 10% |
Testing and diagnosis research | 1 | 3% |
Clinical study results | 1 | 3% |
New treatment approaches | 1 | 3% |
Shah P (2026). [PMID: 41513509](https://pubmed.ncbi.nlm.nih.gov/41513509/). *Seminars in roentgenology*. [Diagnostic / Biomarker]
Yu F (2026). [PMID: 41543088](https://pubmed.ncbi.nlm.nih.gov/41543088/). *Clinical laboratory*. [Case Report / Case Series]
Mu XD (2026). [PMID: 41820048](https://pubmed.ncbi.nlm.nih.gov/41820048/). *Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases*. [Case Report / Case Series]
Yılmaz Aİ (2026). [PMID: 41725300](https://pubmed.ncbi.nlm.nih.gov/41725300/). *Pediatric pulmonology*. [Case Report / Case Series]
Garancini N (2026). [PMID: 41732710](https://pubmed.ncbi.nlm.nih.gov/41732710/). *Respiratory medicine case reports*. [Case Report / Case Series]
Varon-Vega F (2026). [PMID: 41953042](https://pubmed.ncbi.nlm.nih.gov/41953042/). *Case Rep Pathol*. [Case Report / Case Series]
LaFreniere K (2026). [PMID: 32644388](https://pubmed.ncbi.nlm.nih.gov/32644388/). *Unknown Journal*. [Review / Meta-Analysis]
Madu A (2026). [PMID: 32491447](https://pubmed.ncbi.nlm.nih.gov/32491447/). *Unknown Journal*. [Review / Meta-Analysis]
AlAgeel R (2026). [PMID: 42087240](https://pubmed.ncbi.nlm.nih.gov/42087240/). *J Med Case Rep*. [Case Report / Case Series]
Beddi LH (2026). [PMID: 42153155](https://pubmed.ncbi.nlm.nih.gov/42153155/). *Pan Afr Med J*. [Case Report / Case Series]
AI-curated news mentioning pulmonary hemosiderosis
Updated Jun 8, 2026
A case report highlights the use of rituximab as a steroid-sparing therapy in pediatric patients with idiopathic pulmonary hemosiderosis. This approach may offer a new treatment strategy for managing this rare condition.
A recent case report highlights the complexities of diagnosing idiopathic pulmonary hemosiderosis, emphasizing the potential for misleading patient history. The report includes a review of existing literature, contributing to the understanding of this rare condition.
A case report details successful bilateral lung transplantation in a patient with lymphangioleiomyomatosis complicated by secondary pulmonary hemosiderosis. This study contributes to the understanding of treatment options for this rare lung disease.