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Punctate palmoplantar keratoderma type 2 is a type of isolated, punctate, hereditary palmoplantar keratoderma characterized by multiple, asymptomatic, 1 to 2 mm-long, firm, hyperkeratotic projections ("spiny keratosis") on the palms, soles and digits (typically confined to their volar and/or lateral aspects). Histopathologically, compact columnar parakeratosis over hypo- or agranular epidermis is observed.
Features include: Porokeratosis and Spinous keratoses of palms and soles.
Biomarker and diagnostic research for punctate palmoplantar keratoderma type 2 has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for punctate palmoplantar keratoderma type 2.
110 publications have been identified in PubMed for punctate palmoplantar keratoderma type 2. Research spans Case Report / Case Series (45%), Review / Meta-Analysis (21%), and Other (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 50 | 45% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 1:00 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries
23 |
21% |
Other research | 17 | 15% |
Clinical study results | 5 | 5% |
Disease patterns and progression | 5 | 5% |
Testing and diagnosis research | 4 | 4% |
Laboratory research | 4 | 4% |
New treatment approaches | 2 | 2% |
Aguero R (2026). [PMID: 41912153](https://pubmed.ncbi.nlm.nih.gov/41912153/). *Dermatol Pract Concept*. [Epidemiology / Natural History]
Yang Y (2026). [PMID: 41240373](https://pubmed.ncbi.nlm.nih.gov/41240373/). *Br J Dermatol*. [Basic Science / Preclinical]
Jans LYS (2026). [PMID: 41906820](https://pubmed.ncbi.nlm.nih.gov/41906820/). *Br J Dermatol*. [Review / Meta-Analysis]
Lo HM (2026). [PMID: 41787503](https://pubmed.ncbi.nlm.nih.gov/41787503/). *Australas J Dermatol*. [Case Report / Case Series]
Busch DA (2026). [PMID: 40828376](https://pubmed.ncbi.nlm.nih.gov/40828376/). *Dermatologie (Heidelb)*. [Case Report / Case Series]
Tanigassalame P Dr (2026). [PMID: 41490123](https://pubmed.ncbi.nlm.nih.gov/41490123/). *QJM*. [Diagnostic / Biomarker]
Peddireddy G (2026). [PMID: 41841075](https://pubmed.ncbi.nlm.nih.gov/41841075/). *Cureus*. [Case Report / Case Series]
Martini J (2026). [PMID: 41606785](https://pubmed.ncbi.nlm.nih.gov/41606785/). *Clin Exp Dermatol*. [Review / Meta-Analysis]
Le C (2026). [PMID: 29083728](https://pubmed.ncbi.nlm.nih.gov/29083728/). *Unknown Journal*. [Review / Meta-Analysis]
Liu W (2026). [PMID: 42139042](https://pubmed.ncbi.nlm.nih.gov/42139042/). *JAMA Dermatol*. [Epidemiology / Natural History]