RAD51C-related cancer predisposition is a hereditary condition caused by changes in the RAD51C gene. People with this condition have a higher risk for developing tumors at multiple sites. In particular, variations in the RAD51C gene can increase the risk of ovarian cancer as well as certain types of breast cancer, including triple negative and ER negative breast cancer. This condition is passed down in an autosomal dominant pattern, which means that inheriting one copy of the altered gene is enough to increase the risk of tumor development. It is important to note that having the genetic change does not mean that a person will definitely develop cancer, but it does raise the risk compared to the general population.

Information about symptoms is currently limited for this condition.

This condition is caused by pathogenic germline variations in the RAD51C gene. The genetic change is inherited in an autosomal dominant manner, which means that inheriting one copy of the altered gene from a parent may increase the risk of tumor formation in various parts of the body.