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reactive arthritis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

reactive arthritis

MONDO:0017376

Also known as:Fiessinger Leroy Reiter syndromeFiessinger-Leroy diseaseReiter disease

Find Clinical TrialsTrials

Overview

Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.

Clinical Trials5 registered · 2 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Conjunctivitis, Thickened, rough skin (hyperkeratosis), Joint inflammation (arthritis), and Joint swelling and others; and common findings: Skin rash, Iritis, Abdominal pain, and Inflammation of the large intestine and others. 36 total HPO annotations.

Organ System	Phenotype Count	Example Features
Bones and joints	6	Joint inflammation (arthritis), Joint swelling, Joint stiffness

Diagnosis

Biomarker and diagnostic research for reactive arthritis has been reported in the published literature.

Prognosis

Phenotype severity distribution: 15 very common features, 6 common features.

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

5 clinical trials registered, 2 recruiting. Interventions under study include other interventions and drug therapy. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04751396](https://clinicaltrials.gov/study/NCT04751396)

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 8:02 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:29207

GARD

Genetic and Rare Diseases Info Center

GARD:5693

Questions for Your Care Team

→Are any of the 5 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	33	37%
Patient case studies	25	28%
Disease patterns and progression	11	12%
Testing and diagnosis research	9	10%
Laboratory research	8	9%
Clinical study results	2	2%
Other research	1	1%

Kisho

reactive arthritis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

reactive arthritis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications