Lab test results

13

Elevated circulating hepatic transaminase concentration, Elevated creatine kinase (muscle enzyme) (elevated circulating creatine kinase concentration), Elevated circulating aldolase concentration

Lungs and breathing

7

Difficulty breathing (respiratory insufficiency), Recurrent respiratory infections, Lung scarring (pulmonary fibrosis)

Muscles

7

Difficulty breathing due to muscle weakness (respiratory insufficiency due to muscle weakness), EMG: myopathic abnormalities, Limb-girdle muscle weakness

Heart and blood vessels

5

Myocardial infarction, Pericarditis, High blood pressure in lung arteries (pulmonary arterial hypertension)

Blood and immune system

4

Recurrent respiratory infections, Autoimmunity, Vasculitis

Digestive system

4

Elevated circulating hepatic transaminase concentration, Difficulty swallowing (dysphagia), Feeding difficulties in infancy

Brain and nerves

3

Fatigue, Dysphonia, Difficulty swallowing (dysphagia)

Bones and joints

2

Arthralgia, Joint inflammation (arthritis)

Growth and development

1

Weight loss

Arms and legs

1

Limb-girdle muscle weakness

Head and neck

1

Facial erythema

Metabolism

1

Fever

Neoplasm

1

Neoplasm

Gammaplex

Immune Globulin Intravenous (Human)

—

2009

Available

Octagam

Immune Globulin Intravenous (Human)

—

2004

Available

Flebogamma 5%, Flebogamma 5% Dif

Immune Globulin Intravenous (Human)

—

2003

Available

Carimune, Carimune Nf, Panglobulin, Sandoglobulin

Immune Globulin Intravenous (Human)

—

2000

Available

gammar i.v.,gammar-p i.v.

Immune Globulin Intravenous (Human)

—

2000

Available

Gammagard, Gammagard S/D, Iveegam

Immune Globulin Intravenous (Human)

—

1986

Available

Gamimune

Immune Globulin Intravenous (Human)

—

1981

Available

[NCT06698796](https://clinicaltrials.gov/study/NCT06698796)

A Study to Understand How the Study Medicine Dazukibart Works in People With Idiopathic Inflammatory Myopathies

PHASE3

Pfizer

RECRUITING

[NCT06672822](https://clinicaltrials.gov/study/NCT06672822)

Intralesional Injection of STS in Treatment of Calcinosis

PHASE2

Robyn T. Domsic, MD, MPH

RECRUITING

[NCT06154252](https://clinicaltrials.gov/study/NCT06154252)

RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy

PHASE2

Cabaletta Bio

RECRUITING

[NCT07160205](https://clinicaltrials.gov/study/NCT07160205)

Safety and Efficacy of ULSC on Disease Severity and Steroid Tapering in Participants With Dermatomyositis/ Polymyositis (DM/PM), Also Known as Idiopathic Inflammatory Myopathy (IIM)

PHASE2

Restem, LLC.

RECRUITING