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Eosinophilic fasciitis is a rare connective tissue disease that is characterized by inflammation and thickening of the fascia, usually associated with peripheral eosinophilia. It presents during adulthood with symmetrical and painful swelling of mainly the extremities that progressively become indurated. Fatigue, disabling cutaneous fibrosis, myositis and arthritis may also be observed.
Features include very common findings: Edema, Acrocyanosis, Subcutaneous nodule, and Abnormal eosinophil morphology and others; and common findings: Joint inflammation (arthritis) and Arthralgia. 17 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Bones and joints | 2 | Joint inflammation (arthritis), Arthralgia |
Biomarker and diagnostic research for eosinophilic fasciitis has been reported in the published literature.
Phenotype severity distribution: 10 very common features, 2 common features.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.
87 publications have been identified in PubMed for eosinophilic fasciitis. Research spans Case Report / Case Series (49%), Review / Meta-Analysis (23%), and Diagnostic / Biomarker (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 43 | 49% |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 6:56 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Muscles
2 |
Myalgia, Muscular edema |
Brain and nerves | 2 | Paresthesia, Fatigue |
Skin | 1 | Subcutaneous nodule |
Growth and development | 1 | Weight loss |
Research summaries |
20 |
23% |
Testing and diagnosis research | 12 | 14% |
Disease patterns and progression | 4 | 5% |
Other research | 3 | 3% |
Clinical study results | 3 | 3% |
Laboratory research | 2 | 2% |
Sahebari M (2026). [PMID: 41497777](https://pubmed.ncbi.nlm.nih.gov/41497777/). *Clinical case reports*. [Case Report / Case Series]
He J (2026). [PMID: 41877208](https://pubmed.ncbi.nlm.nih.gov/41877208/). *Thrombosis journal*. [Case Report / Case Series]
Ellis JR (2026). [PMID: 41763542](https://pubmed.ncbi.nlm.nih.gov/41763542/). *Pediatrics in review*. [Review / Meta-Analysis]
Fernández Martínez M (2026). [PMID: 40817660](https://pubmed.ncbi.nlm.nih.gov/40817660/). *International journal of dermatology*. [Case Report / Case Series]
Stabile G (2026). [PMID: 42206556](https://pubmed.ncbi.nlm.nih.gov/42206556/). *Ital J Dermatol Venerol*. [Review / Meta-Analysis]
Bruijn TVM (2026). [PMID: 42253044](https://pubmed.ncbi.nlm.nih.gov/42253044/). *J Eur Acad Dermatol Venereol*. [Epidemiology / Natural History]
Crisler WJ (2026). [PMID: 40451539](https://pubmed.ncbi.nlm.nih.gov/40451539/). *The Journal of investigative dermatology*. [Basic Science / Preclinical]
Chew-Bonilla E (2026). [PMID: 41417853](https://pubmed.ncbi.nlm.nih.gov/41417853/). *Revista medica del Instituto Mexicano del Seguro Social*. [Review / Meta-Analysis]
Ali SB (2026). [PMID: 41331198](https://pubmed.ncbi.nlm.nih.gov/41331198/). *Clinical rheumatology*. [Case Report / Case Series]
Cheung DM (2026). [PMID: 41972259](https://pubmed.ncbi.nlm.nih.gov/41972259/). *Pediatr Dermatol*. [Case Report / Case Series]
AI-curated news mentioning eosinophilic fasciitis
Updated Jul 18, 2026
A systematic review highlights favorable clinical outcomes for biologic and targeted therapies in patients with refractory eosinophilic fasciitis. This case-based analysis provides insights into potential treatment options for this rare condition.
A recent study published in PubMed highlights the association between immune checkpoint inhibitors and eosinophilic fasciitis, providing valuable insights into this rare condition. The findings may inform future pharmacovigilance efforts and clinical management strategies.
A comprehensive systematic review on eosinophilic fasciitis highlights clinical, histologic, and therapeutic insights. This review consolidates existing knowledge, potentially guiding future research and treatment strategies.