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A diffuse large B-cell lymphoma characterized by less than 50 percent decrease in lesion size with induction therapy or the appearance of new lesions or the appearance of new lesions after attainment of complete remission.
Biomarker and diagnostic research for relapsed/refractory diffuse large B-cell lymphoma has been reported in the published literature.
25 clinical trials registered, 9 recruiting. Interventions under study include drug therapy, biologic therapy, other interventions, and procedural interventions. Pipeline includes 5 PHASE3, 11 PHASE2, 8 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07409428](https://clinicaltrials.gov/study/NCT07409428) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:49 PM UTC
A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory DLBCL |
PHASE3 |
Hutchmed |
RECRUITING |
[NCT05659628](https://clinicaltrials.gov/study/NCT05659628) | CD19 CAR-T Expressing IL-7 and CCL19 Combined With Anti-PD1 in RR-DLBCL | PHASE1 | Ningbo No. 1 Hospital | RECRUITING |
[NCT06902012](https://clinicaltrials.gov/study/NCT06902012) | Safety and Efficacy of Early Second Infusion of Axi-cel Based on ctDNA for R/R Large B - Cell Lymphoma | PHASE1 | Zhujiang Hospital | RECRUITING |
[NCT05672251](https://clinicaltrials.gov/study/NCT05672251) | Loncastuximab Tesirine and Mosunetuzumab for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma | PHASE2 | City of Hope Medical Center | RECRUITING |
[NCT06867536](https://clinicaltrials.gov/study/NCT06867536) | Hypofractionation Radiotherapy in Combination With Glofitamab in Relapsed/Refractory Diffuse B-cell Lymphoma With Baseline High Tumor Burden | PHASE2 | Liling Zhang | RECRUITING |
174 publications have been identified in PubMed for relapsed/refractory diffuse large B-cell lymphoma. Research spans Clinical Trial Publication (39%), Review / Meta-Analysis (13%), and Case Report / Case Series (13%).
Research Type | Count | % of Total |
|---|---|---|
Clinical study results | 68 | 39% |
Research summaries | 22 | 13% |
Patient case studies | 22 | 13% |
Laboratory research | 18 | 10% |
Disease patterns and progression | 18 | 10% |
Testing and diagnosis research | 13 | 7% |
New treatment approaches | 8 | 5% |
Other research | 5 | 3% |
Di Iasio S (2026). [PMID: 42198346](https://pubmed.ncbi.nlm.nih.gov/42198346/). *Pharmaceuticals (Basel)*. [Diagnostic / Biomarker]
Johnson NA (2026). [PMID: 41367262](https://pubmed.ncbi.nlm.nih.gov/41367262/). *Future oncology (London, England)*. [Clinical Trial Publication]
Tang E (2026). [PMID: 42112708](https://pubmed.ncbi.nlm.nih.gov/42112708/). *Cancer Immunol Res*. [Basic Science / Preclinical]
Kyvsgaard ER (2026). [PMID: 41811794](https://pubmed.ncbi.nlm.nih.gov/41811794/). *Leuk Lymphoma*. [Epidemiology / Natural History]
Jung K (2026). [PMID: 41927037](https://pubmed.ncbi.nlm.nih.gov/41927037/). *Cancer Res Treat*. [Clinical Trial Publication]
Arai Y (2026). [PMID: 41963752](https://pubmed.ncbi.nlm.nih.gov/41963752/). *Clin Drug Investig*. [Other]
Wahid SFA (2026). [PMID: 40576066](https://pubmed.ncbi.nlm.nih.gov/40576066/). *Asia Pac J Clin Oncol*. [Epidemiology / Natural History]
Yoon SE (2026). [PMID: 41364878](https://pubmed.ncbi.nlm.nih.gov/41364878/). *Blood advances*. [Diagnostic / Biomarker]
Marinoni M (2026). [PMID: 41259996](https://pubmed.ncbi.nlm.nih.gov/41259996/). *Curr Res Transl Med*. [Case Report / Case Series]
Kim C (2026). [PMID: 41850221](https://pubmed.ncbi.nlm.nih.gov/41850221/). *Korean J Intern Med*. [Epidemiology / Natural History]