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renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions

MONDO:0006397

Also known as:TFE3-Rearranged renal cell carcinomaXp11.2 translocation-related renal cell carcinomarenal cell cancer associated with Xp11.2 translocations/TFE3 Gene fusions

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Overview

A group of kidney carcinomas characterized by the presence of different translocations involving the chromosome Xp11.2. These translocations result in the creation of gene fusions involving the TFE3 gene. Patients are usually children and young adults. Morphologically, the malignant epithelial cells form papillary patterns.

Clinical Trials3 registered

Diagnosis

Biomarker and diagnostic research for renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered. Interventions under study include drug therapy and biologic therapy. Pipeline includes 2 PHASE2. Research is primarily sponsored by academic and government institutions.

52 publications have been identified in PubMed for renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions. Research spans Case Report / Case Series (37%), Basic Science / Preclinical (35%), and Diagnostic / Biomarker (12%).

Research Type	Count	% of Total
Patient case studies	19

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 7:14 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

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renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions

Overview

Diagnosis

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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