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renal hypoplasia, bilateral - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

renal hypoplasia, bilateral

MONDO:0019980

Overview

Bilateral renal hypoplasia is a form of renal hypoplasia, a renal developmental anomaly in which both kidneys are small and have a deficit in the number of nephrons present.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Renal hypoplasia; and common findings: Vesicoureteral reflux, Protein in the urine (proteinuria), Renal cyst, and Hypertension and others. 31 total HPO annotations.

Organ System	Phenotype Count	Example Features
Kidneys and urinary system	6	Renal hypoplasia, Protein in the urine (proteinuria), Renal cyst

Diagnosis

Biomarker and diagnostic research for renal hypoplasia, bilateral has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 very common feature, 9 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for renal hypoplasia, bilateral.

201 publications have been identified in PubMed for renal hypoplasia, bilateral. Kisho has analyzed 73 by research type. Research spans Case Report / Case Series (44%), Epidemiology / Natural History (19%), and Review / Meta-Analysis (16%).

Research Type	Count	% of Total
Patient case studies	32	44%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 3:32 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:97362

GARD

Genetic and Rare Diseases Info Center

GARD:19374

Questions for Your Care Team

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Kisho

renal hypoplasia, bilateral

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

renal hypoplasia, bilateral

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications