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renal nutcracker syndrome (RNS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

renal nutcracker syndrome

MONDO:0019105

Also known as:RNSleft renal vein entrapment syndromenutcracker syndrome

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Overview

A rare, syndromic renal disease characterized by the entrapment of left renal vein (LRV) between the superior mesenteric artery (SMA) and the abdominal aorta, resulting in increased luminal pressure, renal hilar varices, hematuria and, at the microscopic level, rupture of thin-walled veins into the collecting system in renal fornices.

Clinical Trials1 registered

Diagnosis

Biomarker and diagnostic research for renal nutcracker syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include procedural interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.

110 publications have been identified in PubMed for renal nutcracker syndrome. Kisho has analyzed 83 by research type. Research spans Case Report / Case Series (53%), Review / Meta-Analysis (23%), and Clinical Trial Publication (11%).

Research Type	Count	% of Total
Patient case studies	44

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 12:59 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:71273

GARD

Genetic and Rare Diseases Info Center

GARD:11971

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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renal nutcracker syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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