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An acute and potentially fatal metabolic disorder characterized by cerebral edema, fatty liver and hypoglycemia. It occurs primarily in children and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use.
No clinical trials have been registered for Reye syndrome.
12 publications have been identified in PubMed for Reye syndrome. Kisho has analyzed 8 by research type. Research spans Review / Meta-Analysis (50%), Basic Science / Preclinical (25%), and Epidemiology / Natural History (25%).
Puhan A (2026). [PMID: 42243355](https://pubmed.ncbi.nlm.nih.gov/42243355/). *Protoplasma*. [Review / Meta-Analysis]
Beckers L (2026). [PMID: 42073156](https://pubmed.ncbi.nlm.nih.gov/42073156/). *Children (Basel)*. [Review / Meta-Analysis]
Hon KL (2025). [PMID: 41310409](https://pubmed.ncbi.nlm.nih.gov/41310409/). *Hong Kong medical journal = Xianggang yi xue za zhi*. [Epidemiology / Natural History]
Gibson C (2025). [PMID: 41362566](https://pubmed.ncbi.nlm.nih.gov/41362566/). *Cureus*. [Review / Meta-Analysis]
Singh R (2025). [PMID: 38530560](https://pubmed.ncbi.nlm.nih.gov/38530560/). *Journal of fluorescence*. [Basic Science / Preclinical]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:53 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Reye syndrome
Nayak M (2024). [PMID: 38530561](https://pubmed.ncbi.nlm.nih.gov/38530561/). *Journal of fluorescence*. [Basic Science / Preclinical]
Shaw W (2024). [PMID: 39114279](https://pubmed.ncbi.nlm.nih.gov/39114279/). *Integrative medicine (Encinitas, Calif.)*. [Epidemiology / Natural History]