Roch-Leri mesosomatous lipomatosis is a rare, benign disorder that is inherited in an autosomal dominant manner. It is characterized by the development of multiple small lipomas, which are benign fatty tumors averaging 2 to 5 cm in diameter. These growths are typically found in the middle third of the body, affecting areas such as the forearms, trunk, and upper thighs. The lipomas associated with this condition are generally painless and can be removed by local anesthesia if they are not too numerous or merging together. It is noted that after the initial description in 1984, there has been limited additional information published about this syndrome.

People with this condition develop many small lipomas, usually on the forearms, trunk, and upper thighs. These fat lumps are generally painless, which is one of the notable features of the syndrome. Information on additional symptoms is limited.

Roch-Leri mesosomatous lipomatosis is caused by a genetic change that follows an autosomal dominant inheritance pattern. This means that a change in just one copy of the gene is enough to cause the condition. However, specific details on the underlying genetic mutation or other risk factors are not well described in the literature.