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SAPHO syndrome (PPHS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

SAPHO syndrome

MONDO:0019266

Also known as:PPHSPustulo-psoriatic hyperostotic Spondyloarthritissynovitis, acne, pustulosis palmaris, hyperostosis, osteomyelitis syndrome

Find Clinical TrialsTrials

Overview

SAPHO syndrome (acronym for Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is an auto-inflammatory disease, mainly characterized by the association of neutrophilic cutaneous involvement and chronic osteomyelitis.

Clinical Trials3 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for SAPHO syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 1 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 1 PHASE2. Research is primarily sponsored by academic and government institutions.

156 publications have been identified in PubMed for SAPHO syndrome. Research spans Case Report / Case Series (49%), Review / Meta-Analysis (18%), and Epidemiology / Natural History (9%).

Research Type	Count	% of Total
Patient case studies	76

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:15 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:793

GARD

Genetic and Rare Diseases Info Center

GARD:7606

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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SAPHO syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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