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A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of sciatic neuropathy; radiculopathy (involving the spinal nerve roots; L4, L5, S1, or S2, often associated with intervertebral disk displacement); or lesions of the cauda equina.
Biomarker and diagnostic research for sciatica has been reported in the published literature.
29 clinical trials registered, 13 recruiting. Interventions under study include other interventions, procedural interventions, and drug therapy. Pipeline includes 3 PHASE4, 1 PHASE1, 1 EARLY_PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07418944](https://clinicaltrials.gov/study/NCT07418944) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 11:21 AM UTC
FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation |
NA |
Helsinki University Central Hospital |
RECRUITING |
[NCT07161323](https://clinicaltrials.gov/study/NCT07161323) | SNAG and SNME in Non-Specific Sciatic Pain | NA | Istinye University | RECRUITING |
[NCT06696898](https://clinicaltrials.gov/study/NCT06696898) | Effects of SSMC With and Without Myofascial Release in Patients With Sciatica | NA | Riphah International University | RECRUITING |
[NCT07264270](https://clinicaltrials.gov/study/NCT07264270) | Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy | PHASE1 | Consano Bio | RECRUITING |
[NCT07377357](https://clinicaltrials.gov/study/NCT07377357) | Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of Low-back Related Leg Pain | NA | Universidad Complutense de Madrid | RECRUITING |
217 publications have been identified in PubMed for sciatica. Research spans Review / Meta-Analysis (28%), Clinical Trial Publication (20%), and Basic Science / Preclinical (16%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 54 | 28% |
Clinical study results | 38 | 20% |
Laboratory research | 30 | 16% |
Disease patterns and progression | 29 | 15% |
Patient case studies | 28 | 15% |
Testing and diagnosis research | 8 | 4% |
Other research | 4 | 2% |
New treatment approaches | 2 | 1% |
Lin Y (2026). [PMID: 41656057](https://pubmed.ncbi.nlm.nih.gov/41656057/). *Radiol Clin North Am*. [Review / Meta-Analysis]
Kula H (2026). [PMID: 42208727](https://pubmed.ncbi.nlm.nih.gov/42208727/). *Fertil Steril*. [Case Report / Case Series]
Clackett W (2026). [PMID: 41989203](https://pubmed.ncbi.nlm.nih.gov/41989203/). *Scott Med J*. [Diagnostic / Biomarker]
Klessinger S (2026). [PMID: 41162602](https://pubmed.ncbi.nlm.nih.gov/41162602/). *Orthopadie (Heidelb)*. [Review / Meta-Analysis]
Li J (2026). [PMID: 41781120](https://pubmed.ncbi.nlm.nih.gov/41781120/). *Chin J Nat Med*. [Basic Science / Preclinical]
Jahangeer M (2026). [PMID: 41664189](https://pubmed.ncbi.nlm.nih.gov/41664189/). *J Ethnobiol Ethnomed*. [Epidemiology / Natural History]
Chen J (2026). [PMID: 42237046](https://pubmed.ncbi.nlm.nih.gov/42237046/). *Eur Spine J*. [Basic Science / Preclinical]
Thiagarajah SV (2026). [PMID: 41061105](https://pubmed.ncbi.nlm.nih.gov/41061105/). *Neuroradiol J*. [Epidemiology / Natural History]
Sun Y (2026). [PMID: 42015663](https://pubmed.ncbi.nlm.nih.gov/42015663/). *Folia Morphol (Warsz)*. [Case Report / Case Series]
Sampaio Júnior FAU (2026). [PMID: 41402128](https://pubmed.ncbi.nlm.nih.gov/41402128/). *Int J Spine Surg*. [Clinical Trial Publication]