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segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome

MONDO:0015293

Also known as:SOLAMEN syndrome

Overview

Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome is a rare, genetic, polymalformative syndrome characterized by progressive, proportionate, asymmetric segmental overgrowth (with soft tissue hypertrophy and ballooning effect) that develops and progresses rapidly in early childhood, arteriovenous and lymphatic vascular malformations, lipomatosis and linear epidermal nevus (arranged in whorls along the lines of Blaschko). Clinical symptoms of Cowden syndrome, such as macrocephaly and progressive development of numerous hypertrophic hamartomatous and neoplastic lesions involving multiple organs and systems, are also associated. Patients present an increased risk of developing cancer.

ResearchLimited published research (3 articles)

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome.

3 publications have been identified in PubMed for segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome. Research spans Case Report / Case Series (67%) and Review / Meta-Analysis (33%).

Recent Publications

Torchia D (2026). [PMID: 42241635](https://pubmed.ncbi.nlm.nih.gov/42241635/). *Acta Dermatovenerol Alp Pannonica Adriat*. [Review / Meta-Analysis]
Romanello D (2025). [PMID: 39557791](https://pubmed.ncbi.nlm.nih.gov/39557791/). *Dig Dis Sci*. [Case Report / Case Series]
Zhao X (2024). [PMID: 39080810](https://pubmed.ncbi.nlm.nih.gov/39080810/). *Hereditas*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 9:35 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:137608

GARD

Genetic and Rare Diseases Info Center

GARD:19881

Questions for Your Care Team

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segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome

Overview

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team