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semicircular canal dehiscence syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

semicircular canal dehiscence syndrome

MONDO:0018484

Also known as:Minor's syndromeMinorbs syndromeSCD syndrome

Find Clinical TrialsTrials

Overview

Semicircular canal dehiscence (SCD) syndrome is a rare otorhinolaryngologic disease characterized by the uni- or bilateral dehiscence of the bone(s) overlying the superior (most common), lateral or posterior semicircular canal(s). Patients present audiological (autophony, aural fullness, conductive hearing loss, pulsatile tinnitus) and/or vestibular symptoms (sound or pressure-evoked oscillopsia or vertigo, characteristic vertical-torsional eye movements), depending on which semicircular canal is affected. Posterior SCD syndrome is associated with high-riding jugular bulb and fibrous dysplasia, while lateral SCD syndrome is associated with chronic otitis media and cholesteatoma, with or without audiological and vestibular symptoms.

Clinical Trials1 registered

Diagnosis

Biomarker and diagnostic research for semicircular canal dehiscence syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include other interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.

125 publications have been identified in PubMed for semicircular canal dehiscence syndrome. Kisho has analyzed 81 by research type. Research spans Review / Meta-Analysis (64%), Basic Science / Preclinical (11%), and Case Report / Case Series (7%).

Research Type	Count	% of Total
Research summaries	52

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 3:05 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:420402

GARD

Genetic and Rare Diseases Info Center

GARD:21745

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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semicircular canal dehiscence syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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