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An uncommon cause of hypopituitarism seen after severe postpartum hemorrhaging. Prolonged hypovolemia leads to ischemic necrosis of the pituitary. Clinical signs typically present in the puerperium and include failure to begin lactation, fatigue, hypotension and eventual amenorrhea. Clinical course is usually mild, however extreme cases may progress to adrenal failure. Prognosis is most favorable when hormone replacement is initiated soon after symptom onset.
Biomarker and diagnostic research for Sheehan syndrome has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for Sheehan syndrome.
55 publications have been identified in PubMed for Sheehan syndrome. Research spans Case Report / Case Series (62%), Epidemiology / Natural History (16%), and Review / Meta-Analysis (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 34 | 62% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 1:00 AM UTC
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Sheehan syndrome
9 |
16% |
Research summaries | 8 | 15% |
Testing and diagnosis research | 2 | 4% |
Other research | 1 | 2% |
Clinical study results | 1 | 2% |
Yong X (2026). [PMID: 41737257](https://pubmed.ncbi.nlm.nih.gov/41737257/). *CJC Open*. [Case Report / Case Series]
Chourpiliadi C (2026). [PMID: 31869188](https://pubmed.ncbi.nlm.nih.gov/31869188/). *Unknown Journal*. [Review / Meta-Analysis]
Das L (2026). [PMID: 41363249](https://pubmed.ncbi.nlm.nih.gov/41363249/). *Clin Endocrinol (Oxf)*. [Clinical Trial Publication]
Marimuthu A (2026). [PMID: 42254097](https://pubmed.ncbi.nlm.nih.gov/42254097/). *Ann Med Surg (Lond)*. [Diagnostic / Biomarker]
Wang CY (2026). [PMID: 41501984](https://pubmed.ncbi.nlm.nih.gov/41501984/). *QJM*. [Case Report / Case Series]
Oueslati I (2026). [PMID: 42145665](https://pubmed.ncbi.nlm.nih.gov/42145665/). *J Diabetes Metab Disord*. [Epidemiology / Natural History]
Unknown (2026). [PMID: 42256319](https://pubmed.ncbi.nlm.nih.gov/42256319/). *Case Rep Endocrinol*. [Other]
Ma B (2026). [PMID: 41716316](https://pubmed.ncbi.nlm.nih.gov/41716316/). *Front Surg*. [Case Report / Case Series]
Dameche K (2026). [PMID: 41783865](https://pubmed.ncbi.nlm.nih.gov/41783865/). *Cureus*. [Case Report / Case Series]
Bam N (2026). [PMID: 42175518](https://pubmed.ncbi.nlm.nih.gov/42175518/). *Medicine (Baltimore)*. [Case Report / Case Series]