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A syndrome is characterized by bilateral shortening of the fifth fingers and fifth metacarpals. It has been described in several members of one family. Some members of the family also had spherocytosis and insulin resistance. Transmission is autosomal dominant.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for short fifth metacarpals-insulin resistance syndrome.
5 publications have been identified in PubMed for short fifth metacarpals-insulin resistance syndrome. Research spans Case Report / Case Series (40%), Epidemiology / Natural History (40%), and Gene Therapy / Novel Therapeutics (20%).
Wani MA (2026). [PMID: 41884230](https://pubmed.ncbi.nlm.nih.gov/41884230/). *World J Nephrol*. [Case Report / Case Series]
Ji D (2025). [PMID: 41446595](https://pubmed.ncbi.nlm.nih.gov/41446595/). *Int J Womens Health*. [Epidemiology / Natural History]
Wang G (2025). [PMID: 41130622](https://pubmed.ncbi.nlm.nih.gov/41130622/). *BMJ Paediatr Open*. [Epidemiology / Natural History]
Tung NT (2024). [PMID: 38737445](https://pubmed.ncbi.nlm.nih.gov/38737445/). *Appl Clin Genet*. [Gene Therapy / Novel Therapeutics]
Pragna Lakshmi T (2024). [PMID: 38860410](https://pubmed.ncbi.nlm.nih.gov/38860410/). *Clin Genet*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:40 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center