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A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (alveolitis, extrinsic allergic); allergic rhinitis (rhinitis, allergic, perennial); asthma; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)
No clinical trials have been registered for sick building syndrome.
30 publications have been identified in PubMed for sick building syndrome. Research spans Epidemiology / Natural History (40%), Review / Meta-Analysis (37%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 12 | 40% |
Data assembled from 2 of 12 sources · Last updated Sep 19, 2026, 7:54 AM UTC
Research summaries
11 |
37% |
Laboratory research | 4 | 13% |
Other research | 2 | 7% |
Patient case studies | 1 | 3% |
Wakayama T (2026). [PMID: 41870494](https://pubmed.ncbi.nlm.nih.gov/41870494/). *J Occup Health*. [Basic Science / Preclinical]
Kisielinski K (2026). [PMID: 41937900](https://pubmed.ncbi.nlm.nih.gov/41937900/). *Front Pediatr*. [Review / Meta-Analysis]
Bizuneh B (2026). [PMID: 40464285](https://pubmed.ncbi.nlm.nih.gov/40464285/). *Int J Occup Saf Ergon*. [Epidemiology / Natural History]
Köteles F (2026). [PMID: 41391257](https://pubmed.ncbi.nlm.nih.gov/41391257/). *J Psychosom Res*. [Epidemiology / Natural History]
Abd Razak A (2025). [PMID: 41140948](https://pubmed.ncbi.nlm.nih.gov/41140948/). *Dialogues Health*. [Other]
Chong-Neto HJ (2025). [PMID: 41321708](https://pubmed.ncbi.nlm.nih.gov/41321708/). *Front Allergy*. [Other]
Růžičková J (2025). [PMID: 41440745](https://pubmed.ncbi.nlm.nih.gov/41440745/). *J Xenobiot*. [Basic Science / Preclinical]
Saijo Y (2025). [PMID: 40465554](https://pubmed.ncbi.nlm.nih.gov/40465554/). *PLoS One*. [Epidemiology / Natural History]
Tamran KN (2025). [PMID: 41136502](https://pubmed.ncbi.nlm.nih.gov/41136502/). *Sci Rep*. [Epidemiology / Natural History]
Reddington K (2025). [PMID: 41160934](https://pubmed.ncbi.nlm.nih.gov/41160934/). *J Psychosom Res*. [Epidemiology / Natural History]