An autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or s...
Comprehensive, easy-to-understand information about this condition
How we create this content →The documentation surrounding Sjögren syndrome is limited due to its relatively low prevalence, affecting 1-5 in 10,000 individuals. This rarity restricts the scope of systematic clinical studies, making it challenging to gather comprehensive data. Furthermore, the genetic basis of the condition remains unidentified, complicating the understanding of its pathophysiology and management.
The primary clinical features of Sjögren syndrome include dry eyes (80-99% prevalence) and dry mouth (80-99%). Other common symptoms include positivity for specific antibodies (Anti-La/SS-B and Anti-Ro/SS-A, both 30-79%), skin rash, and arthralgia. Additionally, patients may experience tubulointerstitial nephritis and elevated levels of circulating C-reactive protein and globulin. These symptoms can vary in severity and may affect multiple body systems.
To navigate your care effectively, consider seeking a rheumatologist with expertise in autoimmune disorders, particularly Sjögren syndrome. While there are currently no identified patient organizations specifically for Sjögren syndrome, resources such as the National Organization for Rare Disorders (NORD) at rarediseases.org can provide valuable information and support. Additionally, inquire about participation in clinical trials, as they can offer access to cutting-edge treatments and contribute to the understanding of the condition.
Currently, there are 40 active clinical trials focused on Sjögren syndrome, exploring various aspects of the condition and potential treatments. While there are no orphan drug designations, these trials represent a significant opportunity for patients to participate in research that may lead to new therapeutic options. You can find more information about ongoing studies at ClinicalTrials.gov using the following link: https://clinicaltrials.gov/search?cond=Sjogren%20syndrome.
Actionable guidance for navigating care for Sjogren syndrome
To navigate your care effectively, consider seeking a rheumatologist with expertise in autoimmune disorders, particularly Sjögren syndrome. While there are currently no identified patient organizations specifically for Sjögren syndrome, resources such as the National Organization for Rare Disorders (NORD) at rarediseases.org can provide valuable information and support. Additionally, inquire about participation in clinical trials, as they can offer access to cutting-edge treatments and contribute to the understanding of the condition.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation surrounding Sjögren syndrome is limited due to its relatively low prevalence, affecting 1-5 in 10,000 individuals. This rarity restricts the scope of systematic clinical studies, making it challenging to gather comprehensive data. Furthermore, the genetic basis of the condition remains unidentified, complicating the understanding of its pathophysiology and management.
The primary clinical features of Sjögren syndrome include dry eyes (80-99% prevalence) and dry mouth (80-99%). Other common symptoms include positivity for specific antibodies (Anti-La/SS-B and Anti-Ro/SS-A, both 30-79%), skin rash, and arthralgia. Additionally, patients may experience tubulointerstitial nephritis and elevated levels of circulating C-reactive protein and globulin. These symptoms can vary in severity and may affect multiple body systems.
To navigate your care effectively, consider seeking a rheumatologist with expertise in autoimmune disorders, particularly Sjögren syndrome. While there are currently no identified patient organizations specifically for Sjögren syndrome, resources such as the National Organization for Rare Disorders (NORD) at rarediseases.org can provide valuable information and support. Additionally, inquire about participation in clinical trials, as they can offer access to cutting-edge treatments and contribute to the understanding of the condition.
Currently, there are 40 active clinical trials focused on Sjögren syndrome, exploring various aspects of the condition and potential treatments. While there are no orphan drug designations, these trials represent a significant opportunity for patients to participate in research that may lead to new therapeutic options. You can find more information about ongoing studies at ClinicalTrials.gov using the following link: https://clinicaltrials.gov/search?cond=Sjogren%20syndrome.
Actionable guidance for navigating care for Sjogren syndrome
To navigate your care effectively, consider seeking a rheumatologist with expertise in autoimmune disorders, particularly Sjögren syndrome. While there are currently no identified patient organizations specifically for Sjögren syndrome, resources such as the National Organization for Rare Disorders (NORD) at rarediseases.org can provide valuable information and support. Additionally, inquire about participation in clinical trials, as they can offer access to cutting-edge treatments and contribute to the understanding of the condition.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation surrounding Sjögren syndrome is limited due to its relatively low prevalence, affecting 1-5 in 10,000 individuals. This rarity restricts the scope of systematic clinical studies, making it challenging to gather comprehensive data. Furthermore, the genetic basis of the condition remains unidentified, complicating the understanding of its pathophysiology and management.
The primary clinical features of Sjögren syndrome include dry eyes (80-99% prevalence) and dry mouth (80-99%). Other common symptoms include positivity for specific antibodies (Anti-La/SS-B and Anti-Ro/SS-A, both 30-79%), skin rash, and arthralgia. Additionally, patients may experience tubulointerstitial nephritis and elevated levels of circulating C-reactive protein and globulin. These symptoms can vary in severity and may affect multiple body systems.
To navigate your care effectively, consider seeking a rheumatologist with expertise in autoimmune disorders, particularly Sjögren syndrome. While there are currently no identified patient organizations specifically for Sjögren syndrome, resources such as the National Organization for Rare Disorders (NORD) at rarediseases.org can provide valuable information and support. Additionally, inquire about participation in clinical trials, as they can offer access to cutting-edge treatments and contribute to the understanding of the condition.
Currently, there are 40 active clinical trials focused on Sjögren syndrome, exploring various aspects of the condition and potential treatments. While there are no orphan drug designations, these trials represent a significant opportunity for patients to participate in research that may lead to new therapeutic options. You can find more information about ongoing studies at ClinicalTrials.gov using the following link: https://clinicaltrials.gov/search?cond=Sjogren%20syndrome.
Actionable guidance for navigating care for Sjogren syndrome
To navigate your care effectively, consider seeking a rheumatologist with expertise in autoimmune disorders, particularly Sjögren syndrome. While there are currently no identified patient organizations specifically for Sjögren syndrome, resources such as the National Organization for Rare Disorders (NORD) at rarediseases.org can provide valuable information and support. Additionally, inquire about participation in clinical trials, as they can offer access to cutting-edge treatments and contribute to the understanding of the condition.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Inheritance patterns describe how genetic conditions are passed from parents to children.
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Feb 8, 2026
Consider asking your healthcare providers these condition-specific questions
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
2 peer-reviewed sources from PubMed
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 11 companies have orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.