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Sjogren syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

Sjogren syndrome

MONDO:0010030

Also known as:Sjögren syndromeSjögren-Gougerot syndromeprimary Sjogren-Gougerot syndrome

Find Clinical TrialsTrials

Overview

An autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

GeneticsAutosomal recessive

Clinical Trials25 registered · 9 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Keratoconjunctivitis sicca and Xerostomia; and common findings: Elevated erythrocyte sedimentation rate, Tubulointerstitial nephritis, Increased circulating globulin level, and Anti-La/SS-B antibody positivity and others. 91 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	13	Nervous system problems (abnormality of the nervous system), Anxiety, Fatigue

Diagnosis

Biomarker and diagnostic research for Sjogren syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 very common features, 23 common features.

Estimated prevalence: 1-5 in 10,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

25 clinical trials registered, 9 recruiting. Interventions under study include drug therapy, other interventions, biologic therapy, and medical devices. Pipeline includes 2 PHASE4, 3 PHASE3, 5 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06991114](https://clinicaltrials.gov/study/NCT06991114)

Data assembled from 6 of 12 sources · Last updated Sep 18, 2026, 7:14 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:270150

Orphanet

European rare disease database

Orphanet:289390 Orphanet:378

GARD

Genetic and Rare Diseases Info Center

GARD:10252

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are any of the 25 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	33	45%
Disease patterns and progression	20	27%
Laboratory research	12	16%
Patient case studies	5	7%
Clinical study results	2	3%
Testing and diagnosis research	1	1%
New treatment approaches	1	1%

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Sjogren syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

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Sjogren syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

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Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

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