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Spina bifida-hypospadias syndrome is a rare developmental defect during embryogenesis characterized by the specific association of glandular hypospadias and lumbo-sacral spina bifida. Affected individuals may or may not present additional congenital anomalies, such as hydrocephaly, microstomia, patent ductus arteriosus, cryptorchidism, intestinal malrotation, rocker-bottom feet, and hypertrichosis.
Features include very common findings: Hypospadias, Spina bifida, and Spinal dysraphism.
Biomarker and diagnostic research for spina bifida-hypospadias syndrome has been reported in the published literature.
Phenotype severity distribution: 3 very common features.
No clinical trials have been registered for spina bifida-hypospadias syndrome.
126 publications have been identified in PubMed for spina bifida-hypospadias syndrome. Kisho has analyzed 87 by research type. Research spans Review / Meta-Analysis (28%), Epidemiology / Natural History (28%), and Case Report / Case Series (22%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 24 | 28% |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 12:02 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Disease patterns and progression |
24 |
28% |
Patient case studies | 19 | 22% |
Clinical study results | 6 | 7% |
Laboratory research | 6 | 7% |
Other research | 3 | 3% |
Testing and diagnosis research | 3 | 3% |
New treatment approaches | 2 | 2% |
Munoz JL (2026). [PMID: 41390312](https://pubmed.ncbi.nlm.nih.gov/41390312/). *Semin Perinatol*. [Review / Meta-Analysis]
Sella N (2026). [PMID: 41484689](https://pubmed.ncbi.nlm.nih.gov/41484689/). *J Anesth Analg Crit Care*. [Epidemiology / Natural History]
Di Pietro A (2026). [PMID: 42098511](https://pubmed.ncbi.nlm.nih.gov/42098511/). *Neurol Sci*. [Review / Meta-Analysis]
Yang SH (2026). [PMID: 40377277](https://pubmed.ncbi.nlm.nih.gov/40377277/). *J Adv Nurs*. [Epidemiology / Natural History]
Li Pomi A (2026). [PMID: 41597648](https://pubmed.ncbi.nlm.nih.gov/41597648/). *Microorganisms*. [Review / Meta-Analysis]
Kunpalin Y (2026). [PMID: 41419435](https://pubmed.ncbi.nlm.nih.gov/41419435/). *Prenat Diagn*. [Epidemiology / Natural History]
Park A (2026). [PMID: 41963152](https://pubmed.ncbi.nlm.nih.gov/41963152/). *Sleep Med*. [Review / Meta-Analysis]
Okoye O (2026). [PMID: 41709596](https://pubmed.ncbi.nlm.nih.gov/41709596/). *Neurocase*. [Case Report / Case Series]
Spina S (2026). [PMID: 41319821](https://pubmed.ncbi.nlm.nih.gov/41319821/). *Nitric Oxide*. [Other]
Ali M (2026). [PMID: 41749547](https://pubmed.ncbi.nlm.nih.gov/41749547/). *Children (Basel)*. [Epidemiology / Natural History]
AI-curated news mentioning spina bifida-hypospadias syndrome
Updated Mar 16, 2026
The CDC highlights the importance of independence for individuals with spina bifida as they transition into adulthood. This focus on self-management of health care is crucial for improving quality of life.
The CDC highlights health issues and treatment options for children with spina bifida, aiming to raise awareness and improve care. This initiative focuses on educating families and healthcare providers about the condition.